Editorial: myokines, adipokines, cytokines in muscle pathophysiology, volume II

The maintenance of tissue homeostasis, the coordination of organ functions and the response to pathological insults rely on inter-organ crosstalk. Myokines, adipokines, and cytokines are major peptide mediators of such complex conversation among compartments (de Matos-Neto et al., 2015; Neto et al., 2018). In a previous Research Topic dedicated to this subject we edited a collection of papers discussing the role of these factors in promoting muscle stem cell function and muscle regeneration; as they mediate the effects of exercise upon the muscle and other organs; and their role in disease, when altered levels of these important mediators are described in pathological conditions (Di Felice et al., 2020). With this second Research Topic we expand the discussion, adding to the Research Topic of muscle pathophysiology and inter-organ crosstalk, with a new Research Topic of original papers.