Takotsubo syndrome (TTS) presents as an acute coronary syndrome characterized by severe left ventricular (LV) dysfunction and non-obstructive coronary artery disease that typically shows spontaneous recovery within days or weeks. The mechanisms behind TTS are mainly related to beta-adrenergic overstimulation and acute endogenous catecholamine surge, both of which could increase oxidative status that may induce further deterioration of cardiac function. Although several studies reported evidence of inflammation and oxidative stress overload in myocardial tissue of TTS models, systemic biochemical evidence of augmented oxidant activity in patients with TTS is lacking. In this study, serum samples of ten TTS patients and ten controls have been analyzed using H-1-NMR spectroscopy. The results of this pilot study show a marked alteration in the systemic metabolic profile of TTS patients, mainly characterized by significant elevation of ketone bodies, 2-hydroxybutyrate, acetyl-L-carnitine, and glutamate levels, in contrast with a decrease of several amino acid levels. The overall metabolic fingerprint reflects a systemic response to oxidative stress caused by the stressor that triggered the syndrome's onset.

A pilot study on the 1h-nmr serum metabolic profile of takotsubo patients reveals systemic response to oxidative stress / Vanni, Domitilla; Viceconte, Nicola; Petrella, Greta; Biccirè, Flavio Giuseppe; Pelliccia, Francesco; Tanzilli, Gaetano; Cicero, Daniel Oscar. - In: ANTIOXIDANTS. - ISSN 2076-3921. - 10:12(2021). [10.3390/antiox10121982]

A pilot study on the 1h-nmr serum metabolic profile of takotsubo patients reveals systemic response to oxidative stress

Viceconte, Nicola;Biccirè, Flavio Giuseppe;Pelliccia, Francesco;Tanzilli, Gaetano;
2021

Abstract

Takotsubo syndrome (TTS) presents as an acute coronary syndrome characterized by severe left ventricular (LV) dysfunction and non-obstructive coronary artery disease that typically shows spontaneous recovery within days or weeks. The mechanisms behind TTS are mainly related to beta-adrenergic overstimulation and acute endogenous catecholamine surge, both of which could increase oxidative status that may induce further deterioration of cardiac function. Although several studies reported evidence of inflammation and oxidative stress overload in myocardial tissue of TTS models, systemic biochemical evidence of augmented oxidant activity in patients with TTS is lacking. In this study, serum samples of ten TTS patients and ten controls have been analyzed using H-1-NMR spectroscopy. The results of this pilot study show a marked alteration in the systemic metabolic profile of TTS patients, mainly characterized by significant elevation of ketone bodies, 2-hydroxybutyrate, acetyl-L-carnitine, and glutamate levels, in contrast with a decrease of several amino acid levels. The overall metabolic fingerprint reflects a systemic response to oxidative stress caused by the stressor that triggered the syndrome's onset.
2021
1H-NMR; takotsubo syndrome; metabolomics; systemic stressor response
01 Pubblicazione su rivista::01a Articolo in rivista
A pilot study on the 1h-nmr serum metabolic profile of takotsubo patients reveals systemic response to oxidative stress / Vanni, Domitilla; Viceconte, Nicola; Petrella, Greta; Biccirè, Flavio Giuseppe; Pelliccia, Francesco; Tanzilli, Gaetano; Cicero, Daniel Oscar. - In: ANTIOXIDANTS. - ISSN 2076-3921. - 10:12(2021). [10.3390/antiox10121982]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1658009
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