The p53 tumor suppressor is part of a small family of related proteins that includes two other members, p73 and p63. Interest in the p53 family members, their functions and their complex interactions and regulation, has steadily grown over recent years and does not show signs of waning. p73 is a major determinant of chemosensitivity in humans, and mutant p53 proteins carrying specific polymorphisms can induce drug resistance by inhibiting TAp73. Cooperation between TA (transactivating, proapoptotic, anti proliferative) and Delta N (truncated, antiapoptotic, pro-proliferative) p73 isoforms and among the three family members guarantees equilibrium between proliferation, differentiation, and cell death, thus creating a harmony that is lost in several human cancers. In this article, we review our current knowledge of the role of p73 in cancer chemosensitivity and the real prospect of therapy targeting this molecule. We also draw attention to the crucial role of specific phosphorylation and acetylation events for p73-induced apoptosis and drug chemosensitivity. (Clin Cancer Res 2009;15(21):6495-502)

The p53 family protein p73 provides new insights into cancer chemosensitivity and targeting / P., Lunghi; A., Costanzo; L., Mazzera; V., Rizzoli; Levrero, Massimo; A., Bonati. - In: CLINICAL CANCER RESEARCH. - ISSN 1078-0432. - STAMPA. - 15:21(2009), pp. 6495-6502. [10.1158/1078-0432.ccr-09-1229]

The p53 family protein p73 provides new insights into cancer chemosensitivity and targeting

LEVRERO, Massimo;
2009

Abstract

The p53 tumor suppressor is part of a small family of related proteins that includes two other members, p73 and p63. Interest in the p53 family members, their functions and their complex interactions and regulation, has steadily grown over recent years and does not show signs of waning. p73 is a major determinant of chemosensitivity in humans, and mutant p53 proteins carrying specific polymorphisms can induce drug resistance by inhibiting TAp73. Cooperation between TA (transactivating, proapoptotic, anti proliferative) and Delta N (truncated, antiapoptotic, pro-proliferative) p73 isoforms and among the three family members guarantees equilibrium between proliferation, differentiation, and cell death, thus creating a harmony that is lost in several human cancers. In this article, we review our current knowledge of the role of p73 in cancer chemosensitivity and the real prospect of therapy targeting this molecule. We also draw attention to the crucial role of specific phosphorylation and acetylation events for p73-induced apoptosis and drug chemosensitivity. (Clin Cancer Res 2009;15(21):6495-502)
2009
Apoptosis, DNA-Binding Proteins; antagonists /&/ inhibitors/metabolism, Drug Delivery Systems, Drug Design, Drug Resistance; Neoplasm, Humans, Models; Biological, Mutation, Neoplasms; dr/ug therapy/metabolism, Nuclear Proteins; antagonists /&/ inhibitors/metabolism, Protein Isoforms; metabolism, Tumor Suppressor Protein p53; metabolism, Tumor Suppressor Proteins; antagonists /&/ inhibitors/metabolism
01 Pubblicazione su rivista::01a Articolo in rivista
The p53 family protein p73 provides new insights into cancer chemosensitivity and targeting / P., Lunghi; A., Costanzo; L., Mazzera; V., Rizzoli; Levrero, Massimo; A., Bonati. - In: CLINICAL CANCER RESEARCH. - ISSN 1078-0432. - STAMPA. - 15:21(2009), pp. 6495-6502. [10.1158/1078-0432.ccr-09-1229]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/16578
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