Hypertension is one of the main risk factors for cerebrovascular diseases. This article focuses on the pathophysiological mechanisms recruited by hypertension, altering the normal functioning of the cerebral circulation and conditioning the onset of acute and chronic brain injury. In particular, hypertension favours acute ischaemic and haemorragic events and, more insidiously, chronic neurodegenerative diseases. Indeed, vascular cells, in response to haemodynamic insults, signal to neurons and astrocytes that recruit microglia, which, when activated, secrete several proinflammatory cytokines. The various neuroinflammatory milieu involved in the different clinical manifestations of hypertension-induced cerebrovascular events, contribute in different ways to the onset and progression of brain pathology.
Hypertension and cerebrovascular dysfunction: Acute and chronic brain pathological alterations / Carnevale, D.; Lembo, G.. - In: HIGH BLOOD PRESSURE & CARDIOVASCULAR PREVENTION. - ISSN 1120-9879. - 17:4(2010), pp. 191-200. [10.2165/11311950-000000000-00000]
Hypertension and cerebrovascular dysfunction: Acute and chronic brain pathological alterations
Carnevale, D.
;Lembo, G.
2010
Abstract
Hypertension is one of the main risk factors for cerebrovascular diseases. This article focuses on the pathophysiological mechanisms recruited by hypertension, altering the normal functioning of the cerebral circulation and conditioning the onset of acute and chronic brain injury. In particular, hypertension favours acute ischaemic and haemorragic events and, more insidiously, chronic neurodegenerative diseases. Indeed, vascular cells, in response to haemodynamic insults, signal to neurons and astrocytes that recruit microglia, which, when activated, secrete several proinflammatory cytokines. The various neuroinflammatory milieu involved in the different clinical manifestations of hypertension-induced cerebrovascular events, contribute in different ways to the onset and progression of brain pathology.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.