Evidence shows as Non-Rapid Eye Movements (NREM) sleep suggest a role in protecting the aging brain from neurodegeneration. Moreover, alterations in K-complexs (KCs) features during NREM sleep in Alzheimer's disease patients has been proven. Also in iRBD a recent study highlighted a relation between KC density (KCd) and cognitive functioning, particularly in cognitive domains known to be relevant in predicting conversion into neurodegenerative disorders. However, NREM sleep alterations in RBD and their possible role in cognitive decline, has not yet been extensively investigated. The present study aimed to assess for the first time the existence of KC alterations in iRBD patients compared to Healthy Controls (HC). Methods: KCs were visually scored during Stage 2 NREM sleep in frontal, central and parietal derivations. KCd index was assessed in 31 patients with iRBD (4 F; age: 68.64 ± 6.67 y) and 31 HC (8 F; age: 69.03 ± 6.12 y). We performed a comparison of the KCd between groups. Moreover, we performed the correlation between KCd index, performance in global cognitive function and performance in neuropsychological measures. Results: Results show a significant KCd index reduction in iRBD patients in the frontal, central and parietal derivations compared to HC. In the whole sample the KCd scored in the midline central derivations was correlated positively with Mini-Mental State Examination performances. Moreover, in the iRBD group the midline central KCd index was also positively correlated with scores in attentional matrices and Raven Colored Progressive Matrices. Conclusions: For the first time, our findings describe a clear KCd index reduction in iRBD patients compared to HC. Moreover, we corroborated the relationship between KCd and specific cognitive domains, considered crucial for the prediction of phenoconversion into α-synucleinopathies. With this evidence the present study highlights the need of a further understanding of NREM sleep alterations, and particularly KC features in iRBD, and their possible role to predict neurodegenerative processes. Il giorno mar 25 ott 2022 alle ore 18:27 Luigi De Gennaro ha scritto: P138 | K-complexes density changes in isolated REM sleep behavior disorder and relations with cognitive functioning M. Gorgoni1,2, F. Pietrogiacomi1, F. Reda3, E. Fasiello1, A. Galbiati4,5, M. Camaioni1, S. Scarpelli1, V. Alfonsi1, F. Casoni5, M. Zucconi5, L. Ferini-Strambi4,5, L. De Gennaro1,2 1Sapienza University of Rome, Department of Psychology, Rome, Italy, 2IRCCS Fondazione Santa Lucia, Body and Action Lab, Rome, Italy, 3University of L'Aquila, Department of Biotechnological and Applied Clinical Sciences, L‘Aquila, Italy, 4“Vita-Salute” San Raffaele University, Milan, Italy, 5IRCCS San Raffaele Scientific Institute, Department of Clinical Neurosciences, Neurology – Sleep Disorders Center, Milan, Italy Objectives/introduction: Isolated REM sleep Behaviour Disorder (iRBD) is a Rapid Eye Movements (REM) sleep disorder, representing a prodromal stage of α-synucleinopathies.

K-complexes density changes in isolated REM sleep behavior disorder and relations with cognitive functioning

F. Pietrogiacomi;F. Reda;E. Fasiello;M. Camaioni;S. Scarpelli;L. De Gennaro
2022

Abstract

Evidence shows as Non-Rapid Eye Movements (NREM) sleep suggest a role in protecting the aging brain from neurodegeneration. Moreover, alterations in K-complexs (KCs) features during NREM sleep in Alzheimer's disease patients has been proven. Also in iRBD a recent study highlighted a relation between KC density (KCd) and cognitive functioning, particularly in cognitive domains known to be relevant in predicting conversion into neurodegenerative disorders. However, NREM sleep alterations in RBD and their possible role in cognitive decline, has not yet been extensively investigated. The present study aimed to assess for the first time the existence of KC alterations in iRBD patients compared to Healthy Controls (HC). Methods: KCs were visually scored during Stage 2 NREM sleep in frontal, central and parietal derivations. KCd index was assessed in 31 patients with iRBD (4 F; age: 68.64 ± 6.67 y) and 31 HC (8 F; age: 69.03 ± 6.12 y). We performed a comparison of the KCd between groups. Moreover, we performed the correlation between KCd index, performance in global cognitive function and performance in neuropsychological measures. Results: Results show a significant KCd index reduction in iRBD patients in the frontal, central and parietal derivations compared to HC. In the whole sample the KCd scored in the midline central derivations was correlated positively with Mini-Mental State Examination performances. Moreover, in the iRBD group the midline central KCd index was also positively correlated with scores in attentional matrices and Raven Colored Progressive Matrices. Conclusions: For the first time, our findings describe a clear KCd index reduction in iRBD patients compared to HC. Moreover, we corroborated the relationship between KCd and specific cognitive domains, considered crucial for the prediction of phenoconversion into α-synucleinopathies. With this evidence the present study highlights the need of a further understanding of NREM sleep alterations, and particularly KC features in iRBD, and their possible role to predict neurodegenerative processes. Il giorno mar 25 ott 2022 alle ore 18:27 Luigi De Gennaro ha scritto: P138 | K-complexes density changes in isolated REM sleep behavior disorder and relations with cognitive functioning M. Gorgoni1,2, F. Pietrogiacomi1, F. Reda3, E. Fasiello1, A. Galbiati4,5, M. Camaioni1, S. Scarpelli1, V. Alfonsi1, F. Casoni5, M. Zucconi5, L. Ferini-Strambi4,5, L. De Gennaro1,2 1Sapienza University of Rome, Department of Psychology, Rome, Italy, 2IRCCS Fondazione Santa Lucia, Body and Action Lab, Rome, Italy, 3University of L'Aquila, Department of Biotechnological and Applied Clinical Sciences, L‘Aquila, Italy, 4“Vita-Salute” San Raffaele University, Milan, Italy, 5IRCCS San Raffaele Scientific Institute, Department of Clinical Neurosciences, Neurology – Sleep Disorders Center, Milan, Italy Objectives/introduction: Isolated REM sleep Behaviour Disorder (iRBD) is a Rapid Eye Movements (REM) sleep disorder, representing a prodromal stage of α-synucleinopathies.
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1657416
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact