Purpose To investigate prevalence and predictors of renal function variation in a multicenter cohort treated with radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). Methods Patients from 17 tertiary centers were included. Renal function variation was evaluated at postoperative day (POD)-1, 6 and 12 months. Timepoints differences were Delta 1 = POD-1 eGFR - baseline eGFR; Delta 2 = 6 months eGFR - POD-1 eGFR; Delta 3 = 12 months eGFR - 6 months eGFR. We defined POD-1 acute kidney injury (AKI) as an increase in serum creatinine by >= 0.3 mg/dl or a 1.5 1.9-fold from baseline. Additionally, a cutoff of 60 ml/min in eGFR was considered to define renal function decline at 6 and 12 months. Logistic regression (LR) and linear mixed (LM) models were used to evaluate the association between clinical factors and eGFR decline and their interaction with follow-up. Results A total of 576 were included, of these 409(71.0%) and 403(70.0%) had an eGFR < 60 ml/min at 6 and 12 months, respectively, and 239(41.5%) developed POD-1 AKI. In multivariable LR analysis, age (Odds Ratio, OR 1.05, p < 0.001), male gender (OR 0.44, p = 0.003), POD-1 AKI (OR 2.88, p < 0.001) and preoperative eGFR < 60 ml/min (OR 7.58, p < 0.001) were predictors of renal function decline at 6 months. Age (OR 1.06, p < 0.001), coronary artery disease (OR 2.68, p = 0.007), POD-1 AKI (OR 1.83, p = 0.02), and preoperative eGFR < 60 ml/min (OR 7.80, p < 0.001) were predictors of renal function decline at 12 months. In LM models, age (p = 0.019), hydronephrosis (p < 0.001), POD-1 AKI (p < 0.001) and pT-stage (p = 0.001) influenced renal function variation (ss 9.2 +/- 0.7, p < 0.001) during follow-up. Conclusion Age, preoperative eGFR and POD-1 AKI are independent predictors of 6 and 12 months renal function decline after RNU for UTUC.

Changes in renal function after nephroureterectomy for upper urinary tract carcinoma: analysis of a large multicenter cohort (Radical Nephroureterectomy Outcomes (RaNeO) Research Consortium) / Tafuri, Alessandro; Marchioni, Michele; Cerrato, Clara; Mari, Andrea; Tellini, Riccardo; Odorizzi, Katia; Veccia, Alessandro; Amparore, Daniele; Shakir, Aliasger; Carbonara, Umberto; Panunzio, Andrea; Trovato, Federica; Catellani, Michele; Janello, Letizia M I; Bianchi, Lorenzo; Novara, Giacomo; Dal Moro, Fabrizio; Schiavina, Riccardo; De Lorenzis, Elisa; Parma, Paolo; Cimino, Sebastiano; De Cobelli, Ottavio; Maiorino, Francesco; Bove, Pierluigi; Crocerossa, Fabio; Cantiello, Francesco; D'Andrea, David; Di Cosmo, Federica; Porpiglia, Francesco; Ditonno, Pasquale; Montanari, Emanuele; Soria, Francesco; Gontero, Paolo; Liguori, Giovanni; Trombetta, Carlo; Mantica, Guglielmo; Borghesi, Marco; Terrone, Carlo; Del Giudice, Francesco; Sciarra, Alessandro; Galosi, Andrea; Moschini, Marco; Shariat, Shahrokh F; Di Nicola, Marta; Minervini, Andrea; Ferro, Matteo; Cerruto, Maria Angela; Schips, Luigi; Pagliarulo, Vincenzo; Antonelli, Alessandro. - In: WORLD JOURNAL OF UROLOGY. - ISSN 0724-4983. - (2022). [10.1007/s00345-022-04156-3]

Changes in renal function after nephroureterectomy for upper urinary tract carcinoma: analysis of a large multicenter cohort (Radical Nephroureterectomy Outcomes (RaNeO) Research Consortium)

Mari, Andrea;Trovato, Federica;D'Andrea, David;Liguori, Giovanni;Trombetta, Carlo;Del Giudice, Francesco;Sciarra, Alessandro;Minervini, Andrea;Schips, Luigi;Antonelli, Alessandro
2022

Abstract

Purpose To investigate prevalence and predictors of renal function variation in a multicenter cohort treated with radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). Methods Patients from 17 tertiary centers were included. Renal function variation was evaluated at postoperative day (POD)-1, 6 and 12 months. Timepoints differences were Delta 1 = POD-1 eGFR - baseline eGFR; Delta 2 = 6 months eGFR - POD-1 eGFR; Delta 3 = 12 months eGFR - 6 months eGFR. We defined POD-1 acute kidney injury (AKI) as an increase in serum creatinine by >= 0.3 mg/dl or a 1.5 1.9-fold from baseline. Additionally, a cutoff of 60 ml/min in eGFR was considered to define renal function decline at 6 and 12 months. Logistic regression (LR) and linear mixed (LM) models were used to evaluate the association between clinical factors and eGFR decline and their interaction with follow-up. Results A total of 576 were included, of these 409(71.0%) and 403(70.0%) had an eGFR < 60 ml/min at 6 and 12 months, respectively, and 239(41.5%) developed POD-1 AKI. In multivariable LR analysis, age (Odds Ratio, OR 1.05, p < 0.001), male gender (OR 0.44, p = 0.003), POD-1 AKI (OR 2.88, p < 0.001) and preoperative eGFR < 60 ml/min (OR 7.58, p < 0.001) were predictors of renal function decline at 6 months. Age (OR 1.06, p < 0.001), coronary artery disease (OR 2.68, p = 0.007), POD-1 AKI (OR 1.83, p = 0.02), and preoperative eGFR < 60 ml/min (OR 7.80, p < 0.001) were predictors of renal function decline at 12 months. In LM models, age (p = 0.019), hydronephrosis (p < 0.001), POD-1 AKI (p < 0.001) and pT-stage (p = 0.001) influenced renal function variation (ss 9.2 +/- 0.7, p < 0.001) during follow-up. Conclusion Age, preoperative eGFR and POD-1 AKI are independent predictors of 6 and 12 months renal function decline after RNU for UTUC.
2022
Acute Kidney Injury; Chronic Kidney Disease; Radical Nephroureterectomy; Upper tract urothelial carcinoma
01 Pubblicazione su rivista::01a Articolo in rivista
Changes in renal function after nephroureterectomy for upper urinary tract carcinoma: analysis of a large multicenter cohort (Radical Nephroureterectomy Outcomes (RaNeO) Research Consortium) / Tafuri, Alessandro; Marchioni, Michele; Cerrato, Clara; Mari, Andrea; Tellini, Riccardo; Odorizzi, Katia; Veccia, Alessandro; Amparore, Daniele; Shakir, Aliasger; Carbonara, Umberto; Panunzio, Andrea; Trovato, Federica; Catellani, Michele; Janello, Letizia M I; Bianchi, Lorenzo; Novara, Giacomo; Dal Moro, Fabrizio; Schiavina, Riccardo; De Lorenzis, Elisa; Parma, Paolo; Cimino, Sebastiano; De Cobelli, Ottavio; Maiorino, Francesco; Bove, Pierluigi; Crocerossa, Fabio; Cantiello, Francesco; D'Andrea, David; Di Cosmo, Federica; Porpiglia, Francesco; Ditonno, Pasquale; Montanari, Emanuele; Soria, Francesco; Gontero, Paolo; Liguori, Giovanni; Trombetta, Carlo; Mantica, Guglielmo; Borghesi, Marco; Terrone, Carlo; Del Giudice, Francesco; Sciarra, Alessandro; Galosi, Andrea; Moschini, Marco; Shariat, Shahrokh F; Di Nicola, Marta; Minervini, Andrea; Ferro, Matteo; Cerruto, Maria Angela; Schips, Luigi; Pagliarulo, Vincenzo; Antonelli, Alessandro. - In: WORLD JOURNAL OF UROLOGY. - ISSN 0724-4983. - (2022). [10.1007/s00345-022-04156-3]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1657222
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