Coronary microvascular dysfunction (CMD) is a key pathophysiological feature of hypertrophic cardiomyopathy (HCM), contributing to myocardial ischemia and representing a critical determinant of patients' adverse outcome. The molecular mechanisms underlying the morphological and functional changes of CMD are still unknown. Aim of this study was to obtain insights on the molecular pathways associated with microvessel remodeling in HCM.

RNA-seq profiling reveals different pathways between remodeled vessels and myocardium in hypertrophic cardiomyopathy / Pisano, Annalinda; Pera, Loredana Le; Carletti, Raffaella; Cerbelli, Bruna; Pignataro, Maria G; Pernazza, Angelina; Ferre, Fabrizio; Lombardi, Maria; Lazzeroni, Davide; Olivotto, Iacopo; Rimoldi, Ornella E; Foglieni, Chiara; Camici, Paolo G; D'Amati, Giulia. - In: MICROCIRCULATION. - ISSN 1073-9688. - (2022). [10.1111/micc.12790]

RNA-seq profiling reveals different pathways between remodeled vessels and myocardium in hypertrophic cardiomyopathy

Pisano, Annalinda
Co-primo
;
Pera, Loredana Le
Co-primo
;
Carletti, Raffaella;Cerbelli, Bruna;Pignataro, Maria G;Pernazza, Angelina;Ferre, Fabrizio;d'Amati, Giulia
Ultimo
2022

Abstract

Coronary microvascular dysfunction (CMD) is a key pathophysiological feature of hypertrophic cardiomyopathy (HCM), contributing to myocardial ischemia and representing a critical determinant of patients' adverse outcome. The molecular mechanisms underlying the morphological and functional changes of CMD are still unknown. Aim of this study was to obtain insights on the molecular pathways associated with microvessel remodeling in HCM.
2022
coronary microvascular remodeling; hypertrophic cardiomyopathy; pathway enrichment analyses; remodeled arterioles dissected
01 Pubblicazione su rivista::01a Articolo in rivista
RNA-seq profiling reveals different pathways between remodeled vessels and myocardium in hypertrophic cardiomyopathy / Pisano, Annalinda; Pera, Loredana Le; Carletti, Raffaella; Cerbelli, Bruna; Pignataro, Maria G; Pernazza, Angelina; Ferre, Fabrizio; Lombardi, Maria; Lazzeroni, Davide; Olivotto, Iacopo; Rimoldi, Ornella E; Foglieni, Chiara; Camici, Paolo G; D'Amati, Giulia. - In: MICROCIRCULATION. - ISSN 1073-9688. - (2022). [10.1111/micc.12790]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1656957
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