Many people report suffering from post-acute sequelae of COVID-19 or “long- COVID”, but there are still open questions on what actually constitutes long-COVID and how prevalent it is. The current definition of post-acute sequelae of COVID-19 is based on voting using the Delphi-method by the WHO post-COVID-19 working group. It emphasizes long-lasting fatigue, shortness of breath and cognitive dysfunction as the core symptoms of post-acute sequelae of COVID-19. In this international survey study consisting of 13,628 subjects aged 18–99 years from 16 countries of Asia, Europe, North America and South America (May–Dec 2021), we show that post-acute sequelae of COVID-19 symptoms were more prevalent amongst the more severe COVID-19 cases, i.e. those requiring hospitalisation for COVID-19. We also found that long-lasting sleep symptoms are at the core of post-acute sequelae of COVID-19 and associate with the COVID-19 severity when COVID-19 cases are compared with COVID-negative cases. Specifically, fatigue (61.3%), insomnia symptoms (49.6%) and excessive daytime sleepiness (35.8%) were highly prevalent amongst respondents reporting long-lasting symptoms after hospitalisation for COVID-19. Understanding the importance of sleep-related symptoms in post-acute sequelae of COVID-19 has a clinical relevance when diagnosing and treating long-COVID.

Sleep symptoms are essential features of long‐COVID – Comparing healthy controls with COVID‐19 cases of different severity in the international COVID sleep study (ICOSS‐II) / Merikanto, Ilona; Dauvilliers, Yves; Chung, Frances; Wing, Yun Kwok; de Gennaro, Luigi; Holzinger, Brigitte; Bjorvatn, Bjørn; Morin, Charles M.; Penzel, Thomas; Benedict, Christian; Koscec Bjelajac, Adrijana; Chan, Ngan Yin; Espie, Colin A.; Hrubos‐strøm, Harald; Inoue, Yuichi; Korman, Maria; Landtblom, Anne‐marie; Léger, Damien; Matsui, Kentaro; Mota‐rolim, Sergio; Nadorff, Michael R.; Plazzi, Giuseppe; Reis, Catia; Yordanova, Juliana; Partinen, Markku. - In: JOURNAL OF SLEEP RESEARCH. - ISSN 0962-1105. - (2023). [10.1111/jsr.13754]

Sleep symptoms are essential features of long‐COVID – Comparing healthy controls with COVID‐19 cases of different severity in the international COVID sleep study (ICOSS‐II)

de Gennaro, Luigi;
2023

Abstract

Many people report suffering from post-acute sequelae of COVID-19 or “long- COVID”, but there are still open questions on what actually constitutes long-COVID and how prevalent it is. The current definition of post-acute sequelae of COVID-19 is based on voting using the Delphi-method by the WHO post-COVID-19 working group. It emphasizes long-lasting fatigue, shortness of breath and cognitive dysfunction as the core symptoms of post-acute sequelae of COVID-19. In this international survey study consisting of 13,628 subjects aged 18–99 years from 16 countries of Asia, Europe, North America and South America (May–Dec 2021), we show that post-acute sequelae of COVID-19 symptoms were more prevalent amongst the more severe COVID-19 cases, i.e. those requiring hospitalisation for COVID-19. We also found that long-lasting sleep symptoms are at the core of post-acute sequelae of COVID-19 and associate with the COVID-19 severity when COVID-19 cases are compared with COVID-negative cases. Specifically, fatigue (61.3%), insomnia symptoms (49.6%) and excessive daytime sleepiness (35.8%) were highly prevalent amongst respondents reporting long-lasting symptoms after hospitalisation for COVID-19. Understanding the importance of sleep-related symptoms in post-acute sequelae of COVID-19 has a clinical relevance when diagnosing and treating long-COVID.
2023
COVID-19, excessive daytime sleepiness, fatigue, insomnia, pandemic, post-acute sequelae of COVID-19
01 Pubblicazione su rivista::01a Articolo in rivista
Sleep symptoms are essential features of long‐COVID – Comparing healthy controls with COVID‐19 cases of different severity in the international COVID sleep study (ICOSS‐II) / Merikanto, Ilona; Dauvilliers, Yves; Chung, Frances; Wing, Yun Kwok; de Gennaro, Luigi; Holzinger, Brigitte; Bjorvatn, Bjørn; Morin, Charles M.; Penzel, Thomas; Benedict, Christian; Koscec Bjelajac, Adrijana; Chan, Ngan Yin; Espie, Colin A.; Hrubos‐strøm, Harald; Inoue, Yuichi; Korman, Maria; Landtblom, Anne‐marie; Léger, Damien; Matsui, Kentaro; Mota‐rolim, Sergio; Nadorff, Michael R.; Plazzi, Giuseppe; Reis, Catia; Yordanova, Juliana; Partinen, Markku. - In: JOURNAL OF SLEEP RESEARCH. - ISSN 0962-1105. - (2023). [10.1111/jsr.13754]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1656337
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