Objective: The purpose of this study was to investigate the presence of Adenovirus, Epstein-Barr virus (EBV), HHV-6 and cytomegalovirus (CMV) nucleic acids in the gastrointestinal biopsies from active CD patients. Methods: Gastrointestinal biopsies of 40 active CD patients and 40 non-CD patients were collected during the endoscopic investigation of gastrointestinal symptoms. Results: HHV-6B was found in 62.5% of CD patients and in 65% of non-CD individuals, whereas the prevalence of EBV-positive samples was 20 and 10%, respectively. Nucleic acids from HHV-6A, CMV and adenovirus were not detected in any group. Conclusion: These data suggest that these viruses may not play a role in the pathogenesis of acute CD, but they do not exclude the possibility that viruses can act as a trigger for the onset of celiac disease.

Analysis of viral nucleic acids in duodenal biopsies from adult patients with celiac disease / Calabretto, Marianna; DI CARLO, Daniele; Falasca, Francesca; Mazzuti, Laura; Meacci, Arianna; Donato, Giuseppe; Greco, Nicoletta; Mezzatesta, Laura; Morrone, Anna; Turriziani, Ombretta; Picarelli, Antonio. - In: EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY. - ISSN 0954-691X. - (2022).

Analysis of viral nucleic acids in duodenal biopsies from adult patients with celiac disease

Calabretto Marianna;Di Carlo Daniele;Falasca Francesca;Mazzuti Laura;Meacci Arianna;Donato Giuseppe;Greco Nicoletta;Mezzatesta Laura;Morrone Anna;Turriziani Ombretta
;
Picarelli Antonio
2022

Abstract

Objective: The purpose of this study was to investigate the presence of Adenovirus, Epstein-Barr virus (EBV), HHV-6 and cytomegalovirus (CMV) nucleic acids in the gastrointestinal biopsies from active CD patients. Methods: Gastrointestinal biopsies of 40 active CD patients and 40 non-CD patients were collected during the endoscopic investigation of gastrointestinal symptoms. Results: HHV-6B was found in 62.5% of CD patients and in 65% of non-CD individuals, whereas the prevalence of EBV-positive samples was 20 and 10%, respectively. Nucleic acids from HHV-6A, CMV and adenovirus were not detected in any group. Conclusion: These data suggest that these viruses may not play a role in the pathogenesis of acute CD, but they do not exclude the possibility that viruses can act as a trigger for the onset of celiac disease.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1655356
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