Background Bronchiolitis is the most frequent cause of hospitalization in infants younger than 1 year of age. We sought to evaluate the correlation between lymphocyte count and clinical manifestation in infants hospitalized with bronchiolitis. Materials and Methods We performed a retrospective cohort study evaluating 1297 children hospitalized for bronchiolitis from 2004 to 2019. A nasal washing was tested for 14 respiratory viruses by PCR. A clinical severity score, ranging 0-8, was assigned at hospital admission. History and clinical course were recorded for each infant. Patients were divided in 3 groups according to lymphocyte count tertiles. Parents of enrolled patients have been phoned annually over 5 years to evaluate respiratory sequelae. Results A total of 433 children had 2914.2 +/- 745.5/mm(3) lymphocytes (Group 1), 432 had 4897.6 +/- 561.5/mm(3) lymphocytes (Group 2) and 432 had 7884 +/- 1903.3/mm(3) lymphocytes (Group 3). Group 1 patients were more frequently infected by RSV and presented with fever, a worse clinical severity score. They more frequently needed oxygen supplementation, underwent a prolonged hospitalization needed to be admitted to pediatric intensive care unit. Finally, they had more frequently a family history of eczema, wheezing and asthma. We found no differences between lymphocytes count and respiratory sequelae (at least two episodes of wheezing per year). Conclusions Infants with low lymphocyte count are more likely to have a worse clinical course of bronchiolitis.

Low lymphocyte count: A clinical severity marker in infants with bronchiolitis / Matera, Luigi; Nenna, Raffaella; Frassanito, Antonella; Petrarca, Laura; Mancino, Enrica; Rizzo, Valentina; DI MATTIA, Greta; Paolo La Regina, Domenico; Pierangeli, Alessandra; Midulla, Fabio. - In: PEDIATRIC PULMONOLOGY. - ISSN 1099-0496. - 57:7(2022), pp. 1770-1775. [10.1002/ppul.25919]

Low lymphocyte count: A clinical severity marker in infants with bronchiolitis

Luigi Matera;Raffaella Nenna
Secondo
;
Antonella Frassanito;Laura Petrarca;Enrica Mancino;Valentina Rizzo;Greta Di Mattia;Alessandra Pierangeli;Fabio Midulla
Ultimo
2022

Abstract

Background Bronchiolitis is the most frequent cause of hospitalization in infants younger than 1 year of age. We sought to evaluate the correlation between lymphocyte count and clinical manifestation in infants hospitalized with bronchiolitis. Materials and Methods We performed a retrospective cohort study evaluating 1297 children hospitalized for bronchiolitis from 2004 to 2019. A nasal washing was tested for 14 respiratory viruses by PCR. A clinical severity score, ranging 0-8, was assigned at hospital admission. History and clinical course were recorded for each infant. Patients were divided in 3 groups according to lymphocyte count tertiles. Parents of enrolled patients have been phoned annually over 5 years to evaluate respiratory sequelae. Results A total of 433 children had 2914.2 +/- 745.5/mm(3) lymphocytes (Group 1), 432 had 4897.6 +/- 561.5/mm(3) lymphocytes (Group 2) and 432 had 7884 +/- 1903.3/mm(3) lymphocytes (Group 3). Group 1 patients were more frequently infected by RSV and presented with fever, a worse clinical severity score. They more frequently needed oxygen supplementation, underwent a prolonged hospitalization needed to be admitted to pediatric intensive care unit. Finally, they had more frequently a family history of eczema, wheezing and asthma. We found no differences between lymphocytes count and respiratory sequelae (at least two episodes of wheezing per year). Conclusions Infants with low lymphocyte count are more likely to have a worse clinical course of bronchiolitis.
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1655233
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 0
  • ???jsp.display-item.citation.isi??? 0
social impact