Background and aims: Sleep disturbances may promote glucose abnormalities and inflammatory burden among shift workers. Therefore, precocious subclinical atherosclerotic process might develop in healthy shift workers even without known metabolic and cardiovascular risk factors.Methods and results: We measured anthropometric parameters, glucose, lipids, inflammation and common carotid Intimal Medial Thickness (cIMT) in rotating-night shift workers (r-NSW, n = 88, age = 40.3 +/- 7.8 y) in comparison with former-night shift workers (f-NSW, n = 35, age = 44.2 +/- 6.4 y) and with day-only workers (DW, n = 64, age = 44.1 +/- 8.9 y).R-NSW and f-NSW showed significantly higher cIMT and high sensitivity C-Reactive Protein (hs-CRP) respect to DW (p = 0.043 and p = 0.025, respectively). IL-1 beta levels were higher in r-NSW than in DW and f-NSW (p = 0.043) and significantly correlated with IL6 (r = 0.365, p < 0.001). In addition, r-NSW and f-NSW had higher HbA1c levels in comparison with DW (p = 0.047). Carotid-IMT was significantly related to night shift work (p = 0.023), with age (p < 0.001), with HOMA IR (p = 0.009), with insulin (p = 0.006) with HbA1c (p = 0.002), with LDL cholesterol (p < 0.001), with diastolic BP (p < 0.001), with WBC (p = 0.002) and with IL6 (p = 0.004). After performing a multivariate analysis night shift work remained statistically related to cIMT (B = 2.633, 95%CI = 0.489-4.776, p = 0.016).Conclusions: Our result described a possible link bridging night shift work, inflammation and carotid Intimal Medial Thickness. Future studies are warranted to understand if carotid atherosclerosis process should be mainly driven by the IL1 beta/IL6 citokine axis connected to sleep disturbances. (C) 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

Carotid intimal medial thickness in rotating night shift is related to IL1β/IL6 axis / Rizza, Stefano; Longo, Susanna; Piciucchi, Giacomo; Romanello, Daniele; Mavilio, Maria; Montagna, Martina; Coppeta, Luca; Martelli, Eugenio; Magrini, Andrea; Federici, Massimo. - In: NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. - ISSN 0939-4753. - 30:10(2020), pp. 1826-1832. [10.1016/j.numecd.2020.05.028]

Carotid intimal medial thickness in rotating night shift is related to IL1β/IL6 axis

Martelli, Eugenio
Investigation
;
2020

Abstract

Background and aims: Sleep disturbances may promote glucose abnormalities and inflammatory burden among shift workers. Therefore, precocious subclinical atherosclerotic process might develop in healthy shift workers even without known metabolic and cardiovascular risk factors.Methods and results: We measured anthropometric parameters, glucose, lipids, inflammation and common carotid Intimal Medial Thickness (cIMT) in rotating-night shift workers (r-NSW, n = 88, age = 40.3 +/- 7.8 y) in comparison with former-night shift workers (f-NSW, n = 35, age = 44.2 +/- 6.4 y) and with day-only workers (DW, n = 64, age = 44.1 +/- 8.9 y).R-NSW and f-NSW showed significantly higher cIMT and high sensitivity C-Reactive Protein (hs-CRP) respect to DW (p = 0.043 and p = 0.025, respectively). IL-1 beta levels were higher in r-NSW than in DW and f-NSW (p = 0.043) and significantly correlated with IL6 (r = 0.365, p < 0.001). In addition, r-NSW and f-NSW had higher HbA1c levels in comparison with DW (p = 0.047). Carotid-IMT was significantly related to night shift work (p = 0.023), with age (p < 0.001), with HOMA IR (p = 0.009), with insulin (p = 0.006) with HbA1c (p = 0.002), with LDL cholesterol (p < 0.001), with diastolic BP (p < 0.001), with WBC (p = 0.002) and with IL6 (p = 0.004). After performing a multivariate analysis night shift work remained statistically related to cIMT (B = 2.633, 95%CI = 0.489-4.776, p = 0.016).Conclusions: Our result described a possible link bridging night shift work, inflammation and carotid Intimal Medial Thickness. Future studies are warranted to understand if carotid atherosclerosis process should be mainly driven by the IL1 beta/IL6 citokine axis connected to sleep disturbances. (C) 2020 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
2020
IL6/IL-1β; inflammation; intimal-medial-thickness; rotating-night shift workers; adult; biomarkers; carotid artery diseases; carotid artery, common; cross-sectional studies; female; humans; inflammation; inflammation mediators; interleukin-1beta; interleukin-6; male; middle aged; predictive value of tests; risk factors; sleep; sleep disorders, circadian rhythm; time factors; carotid intima-media thickness; shift work schedule
01 Pubblicazione su rivista::01a Articolo in rivista
Carotid intimal medial thickness in rotating night shift is related to IL1β/IL6 axis / Rizza, Stefano; Longo, Susanna; Piciucchi, Giacomo; Romanello, Daniele; Mavilio, Maria; Montagna, Martina; Coppeta, Luca; Martelli, Eugenio; Magrini, Andrea; Federici, Massimo. - In: NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. - ISSN 0939-4753. - 30:10(2020), pp. 1826-1832. [10.1016/j.numecd.2020.05.028]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1655157
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