Introduction: The global COVID-19 pandemic has been associated with high mortality, particularly among the elderly and patients with chronic comorbidities, but the vast majority of affected people are asymptomatic or have only mild symptoms. The aim was to explore associations between treatments used and reported outcomes in patients who developed symptoms and were tested positive for COVID-19. Methods: Adult participants were recruited to participate in an online survey from the general public in 13 countries (Brazil, China, Germany, Greece, Iraq, Italy, Mexico, the Netherlands, South Korea, Sweden, Switzerland, UK, USA), between July 2020 and May 2021. In this analysis we include participants who had symptoms of acute respiratory infection and/ or confirmed COVID-19 infection. A retrospective treatment-outcome approach to analyse statistical associations between treatments used and outcomes (duration and severity of symptoms). Results: Over 54,000 participants completed the online questionnaire, and over 104,000 participants partially answered it. Regression of each outcome on the most frequently used treatments, adjusting for prespecified confounders (including age and comorbidities), will prioritise the treatments associated with the best outcomes. Conclusion: The treatments associated with the best outcomes could be a priority for further research. However, one cannot conclude that these treatments are effective, because it is difficult to control for all confounders, especially baseline severity of illness.

Retrospective Survey of Treatment and Outcomes of COVID-19 in the community

Cristina Mollica;Sara Spadaccini
2021

Abstract

Introduction: The global COVID-19 pandemic has been associated with high mortality, particularly among the elderly and patients with chronic comorbidities, but the vast majority of affected people are asymptomatic or have only mild symptoms. The aim was to explore associations between treatments used and reported outcomes in patients who developed symptoms and were tested positive for COVID-19. Methods: Adult participants were recruited to participate in an online survey from the general public in 13 countries (Brazil, China, Germany, Greece, Iraq, Italy, Mexico, the Netherlands, South Korea, Sweden, Switzerland, UK, USA), between July 2020 and May 2021. In this analysis we include participants who had symptoms of acute respiratory infection and/ or confirmed COVID-19 infection. A retrospective treatment-outcome approach to analyse statistical associations between treatments used and outcomes (duration and severity of symptoms). Results: Over 54,000 participants completed the online questionnaire, and over 104,000 participants partially answered it. Regression of each outcome on the most frequently used treatments, adjusting for prespecified confounders (including age and comorbidities), will prioritise the treatments associated with the best outcomes. Conclusion: The treatments associated with the best outcomes could be a priority for further research. However, one cannot conclude that these treatments are effective, because it is difficult to control for all confounders, especially baseline severity of illness.
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/1654920
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact