The most frequent thyroid cancer is Differentiated Thyroid Cancer (DTC) representing more than 95% of cases. A suitable choice for the treatment of DTC is the systemic administration of 131-sodium or potassium iodide. It is an effective tool used for the irradiation of thyroid remnants, microscopic DTC, other nonresectable or incompletely resectable DTC, or all the cited purposes. Dosimetry represents a valid tool that permits a tailored therapy to be obtained, sparing healthy tissue and so minimizing potential damages to at-risk organs. Absorbed dose represents a reliable indicator of biological response due to its correlation to tissue irradiation effects. The present paper aims to focus attention on iodine therapy for DTC treatment and has developed due to the urgent need for standardization in procedures, since no unique approaches are available. This review aims to summarize new proposals for a dosimetry-based therapy and so explore new alternatives that could provide the possibility to achieve more tailored therapies, minimizing the possible side effects of radioiodine therapy for Differentiated Thyroid Cancer.

Personalized dosimetry in the context of radioiodine therapy for differentiated thyroid cancer / Pacilio, Massimiliano; Conte, Miriam; Frantellizzi, Viviana; De Feo, Maria Silvia; Pisani, Antonio Rosario; Marongiu, Andrea; Nuvoli, Susanna; Rubini, Giuseppe; Spanu, Angela; De Vincentis, Giuseppe. - In: DIAGNOSTICS. - ISSN 2075-4418. - 12:7(2022). [10.3390/diagnostics12071763]

Personalized dosimetry in the context of radioiodine therapy for differentiated thyroid cancer

Pacilio, Massimiliano
Primo
;
Conte, Miriam
Secondo
;
Frantellizzi, Viviana
;
De Feo, Maria Silvia;De Vincentis, Giuseppe
Ultimo
2022

Abstract

The most frequent thyroid cancer is Differentiated Thyroid Cancer (DTC) representing more than 95% of cases. A suitable choice for the treatment of DTC is the systemic administration of 131-sodium or potassium iodide. It is an effective tool used for the irradiation of thyroid remnants, microscopic DTC, other nonresectable or incompletely resectable DTC, or all the cited purposes. Dosimetry represents a valid tool that permits a tailored therapy to be obtained, sparing healthy tissue and so minimizing potential damages to at-risk organs. Absorbed dose represents a reliable indicator of biological response due to its correlation to tissue irradiation effects. The present paper aims to focus attention on iodine therapy for DTC treatment and has developed due to the urgent need for standardization in procedures, since no unique approaches are available. This review aims to summarize new proposals for a dosimetry-based therapy and so explore new alternatives that could provide the possibility to achieve more tailored therapies, minimizing the possible side effects of radioiodine therapy for Differentiated Thyroid Cancer.
2022
Differentiated Thyroid Cancer; absorbed dose; personalized dosimetry; radioiodine therapy
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Personalized dosimetry in the context of radioiodine therapy for differentiated thyroid cancer / Pacilio, Massimiliano; Conte, Miriam; Frantellizzi, Viviana; De Feo, Maria Silvia; Pisani, Antonio Rosario; Marongiu, Andrea; Nuvoli, Susanna; Rubini, Giuseppe; Spanu, Angela; De Vincentis, Giuseppe. - In: DIAGNOSTICS. - ISSN 2075-4418. - 12:7(2022). [10.3390/diagnostics12071763]
File allegati a questo prodotto
File Dimensione Formato  
Pacilio_Personalized-dosimetry_2022.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 399.91 kB
Formato Adobe PDF
399.91 kB Adobe PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1654889
Citazioni
  • ???jsp.display-item.citation.pmc??? 6
  • Scopus 13
  • ???jsp.display-item.citation.isi??? 11
social impact