Simple Summary In this review, we summarize in vitro and in vivo studies related to glioblastoma models and human patients to outline the symbiotic bidirectional interaction between microglia, lymphocytes, and tumor cells that develops during tumor progression. Particularly, we highlight the current experimental therapeutic approaches that aim to shape these interplays, such as adeno-associated virus (AAV) delivery and CAR-T and -NK cell infusion, and to modulate the tumor microenvironment in an anti-tumoral way, thus counteracting glioblastoma growth. Microglia and lymphocytes are fundamental constituents of the glioblastoma microenvironment. In this review, we summarize the current state-of-the-art knowledge of the microglial role played in promoting the development and aggressive hallmarks of this deadly brain tumor. Particularly, we report in vitro and in vivo studies related to glioblastoma models and human patients to outline the symbiotic bidirectional interaction between microglia, lymphocytes, and tumor cells that develops during tumor progression. Furthermore, we highlight the current experimental therapeutic approaches that aim to shape these interplays, such as adeno-associated virus (AAV) delivery and CAR-T and -NK cell infusion, and to modulate the tumor microenvironment in an anti-tumoral way, thus counteracting glioblastoma growth.

Dialogue among Lymphocytes and Microglia in Glioblastoma Microenvironment / Mormino, Alessandro; Garofalo, Stefano. - In: CANCERS. - ISSN 2072-6694. - 14:11(2022), p. 2632. [10.3390/cancers14112632]

Dialogue among Lymphocytes and Microglia in Glioblastoma Microenvironment

Alessandro Mormino
Primo
;
Stefano Garofalo
Ultimo
2022

Abstract

Simple Summary In this review, we summarize in vitro and in vivo studies related to glioblastoma models and human patients to outline the symbiotic bidirectional interaction between microglia, lymphocytes, and tumor cells that develops during tumor progression. Particularly, we highlight the current experimental therapeutic approaches that aim to shape these interplays, such as adeno-associated virus (AAV) delivery and CAR-T and -NK cell infusion, and to modulate the tumor microenvironment in an anti-tumoral way, thus counteracting glioblastoma growth. Microglia and lymphocytes are fundamental constituents of the glioblastoma microenvironment. In this review, we summarize the current state-of-the-art knowledge of the microglial role played in promoting the development and aggressive hallmarks of this deadly brain tumor. Particularly, we report in vitro and in vivo studies related to glioblastoma models and human patients to outline the symbiotic bidirectional interaction between microglia, lymphocytes, and tumor cells that develops during tumor progression. Furthermore, we highlight the current experimental therapeutic approaches that aim to shape these interplays, such as adeno-associated virus (AAV) delivery and CAR-T and -NK cell infusion, and to modulate the tumor microenvironment in an anti-tumoral way, thus counteracting glioblastoma growth.
2022
CAR technology; adeno-associated viruses; cytotoxic lymphocytes; enriched environment; glioblastoma; microglia; natural killer cells
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Dialogue among Lymphocytes and Microglia in Glioblastoma Microenvironment / Mormino, Alessandro; Garofalo, Stefano. - In: CANCERS. - ISSN 2072-6694. - 14:11(2022), p. 2632. [10.3390/cancers14112632]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1654496
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