Age-dependent and sex-dependent disparity in mortality in patients with adrenal incidentalomas and autonomous cortisol secretion. an international, retrospective, cohort study

Deutschbein, Timo; Reimondo, Giuseppe; Di Dalmazi, Guido; Bancos, Irina; Patrova, Jekaterina; Vassiliadi, Dimitra Argyro; Nekić, Anja Barač; Debono, Miguel; Lardo, Pina; Ceccato, Filippo; Petramala, Luigi; Prete, Alessandro; Chiodini, Iacopo; Ivović, Miomira; Pazaitou-Panayiotou, Kalliopi; Alexandraki, Krystallenia I; Hanzu, Felicia Alexandra; Loli, Paola; Yener, Serkan; Langton, Katharina; Spyroglou, Ariadni; Kocjan, Tomaz; Zacharieva, Sabina; Valdés, Nuria; Ambroziak, Urszula; Suzuki, Mari; Detomas, Mario; Puglisi, Soraya; Tucci, Lorenzo; Delivanis, Danae Anastasia; Margaritopoulos, Dimitris; Dusek, Tina; Maggio, Roberta; Scaroni, Carla; Concistrè, Antonio; Ronchi, Cristina Lucia; Altieri, Barbara; Mosconi, Cristina; Diamantopoulos, Aristidis; Iñiguez-Ariza, Nicole Marie; Vicennati, Valentina; Pia, Anna; Kroiss, Matthias; Kaltsas, Gregory; Chrisoulidou, Alexandra; Marina, Ljiljana V; Morelli, Valentina; Arlt, Wiebke; Letizia, Claudio; Boscaro, Marco; Stigliano, Antonio; Kastelan, Darko; Tsagarakis, Stylianos; Athimulam, Shobana; Pagotto, Uberto; Maeder, Uwe; Falhammar, Henrik; Newell-Price, John; Terzolo, Massimo; Fassnacht, Martin

doi:10.1016/S2213-8587(22)00100-0

The association between cortisol secretion and mortality in patients with adrenal incidentalomas is controversial. We aimed to assess all-cause mortality, prevalence of comorbidities, and occurrence of cardiovascular events in uniformly stratified patients with adrenal incidentalomas and cortisol autonomy (defined as non-suppressible serum cortisol on dexamethasone suppression testing).

Age-dependent and sex-dependent disparity in mortality in patients with adrenal incidentalomas and autonomous cortisol secretion. an international, retrospective, cohort study / Deutschbein, T., Reimondo, G., Di Dalmazi, G., Bancos, I., Patrova, J., Vassiliadi, D.A., Nekić, A.B., Debono, M., Lardo, P., Ceccato, F., Petramala, L., Prete, A., Chiodini, I., Ivović, M., Pazaitou-Panayiotou, K., Alexandraki, K.I., Hanzu, F.A., Loli, P., Yener, S., Langton, K., et al.. - In: THE LANCET DIABETES & ENDOCRINOLOGY. - ISSN 2213-8595. - 10:7(2022), pp. 499-508. [10.1016/S2213-8587(22)00100-0]