Testicular cancer (TC) is the most common malignancy among young adult males. The etiology is multifactorial, and both environmental and genetic factors play an essential role in the origin and development of this tumor. In particular, exposure to environmental endocrine disruptors (EEDs), resulting from industrialization and urbanization, seems crucial both in pre-and postnatal life. However, the lack of long-term studies on a wide caseload and the difficulty in evaluating their toxic effects in vivo make it challenging to establish a causal link. This review aims to discuss the main human epidemiological studies currently available in the literature to define a possible association between these chemicals and TC.

Environmental disruptors and testicular cancer / Faja, Fabiana; Esteves, Sandro; Pallotti, Francesco; Cicolani, Gaia; Di Chiano, Silvia; Delli Paoli, Enrico; Lenzi, Andrea; Lombardo, Francesco; Paoli, Donatella. - In: ENDOCRINE. - ISSN 1559-0100. - (2022). [10.1007/s12020-022-03171-z]

Environmental disruptors and testicular cancer

Faja, Fabiana
Primo
;
Pallotti, Francesco;Cicolani, Gaia;Di Chiano, Silvia;Delli Paoli, Enrico;Lenzi, Andrea;Lombardo, Francesco
Penultimo
;
Paoli, Donatella
Ultimo
2022

Abstract

Testicular cancer (TC) is the most common malignancy among young adult males. The etiology is multifactorial, and both environmental and genetic factors play an essential role in the origin and development of this tumor. In particular, exposure to environmental endocrine disruptors (EEDs), resulting from industrialization and urbanization, seems crucial both in pre-and postnatal life. However, the lack of long-term studies on a wide caseload and the difficulty in evaluating their toxic effects in vivo make it challenging to establish a causal link. This review aims to discuss the main human epidemiological studies currently available in the literature to define a possible association between these chemicals and TC.
2022
Environmental endocrine disruptors; Environmental pollution; Male reproductive health; Testicular cancer
01 Pubblicazione su rivista::01a Articolo in rivista
Environmental disruptors and testicular cancer / Faja, Fabiana; Esteves, Sandro; Pallotti, Francesco; Cicolani, Gaia; Di Chiano, Silvia; Delli Paoli, Enrico; Lenzi, Andrea; Lombardo, Francesco; Paoli, Donatella. - In: ENDOCRINE. - ISSN 1559-0100. - (2022). [10.1007/s12020-022-03171-z]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1654042
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