A series of non-peptidic HIV protease inhibitors were synthesized starting from the same optically active precursor, (S)-glycidol. The substrate was easily converted into different indolic sulfonamides or amines by regioselective reactions. The preliminary inhibitory activity was evaluated.
New indolic non-peptidic HIV protease inhibitors from (S)-glycidol:synthesis and preliminary biological activity / Chiummiento, Lucia; Funicello, Maria; Lupattelli, Paolo; F., Tramutola; P., Campaner. - In: TETRAHEDRON. - ISSN 0040-4020. - 65:31(2009), pp. 5984-5989. [10.1016/j.tet.2009.05.089]
New indolic non-peptidic HIV protease inhibitors from (S)-glycidol:synthesis and preliminary biological activity
LUPATTELLI, Paolo;
2009
Abstract
A series of non-peptidic HIV protease inhibitors were synthesized starting from the same optically active precursor, (S)-glycidol. The substrate was easily converted into different indolic sulfonamides or amines by regioselective reactions. The preliminary inhibitory activity was evaluated.File allegati a questo prodotto
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