A series of non-peptidic HIV protease inhibitors were synthesized starting from the same optically active precursor, (S)-glycidol. The substrate was easily converted into different indolic sulfonamides or amines by regioselective reactions. The preliminary inhibitory activity was evaluated.

New indolic non-peptidic HIV protease inhibitors from (S)-glycidol:synthesis and preliminary biological activity

LUPATTELLI, Paolo;
2009

Abstract

A series of non-peptidic HIV protease inhibitors were synthesized starting from the same optically active precursor, (S)-glycidol. The substrate was easily converted into different indolic sulfonamides or amines by regioselective reactions. The preliminary inhibitory activity was evaluated.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/1653091
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