Background: Transthyretin-mediated amyloidosis (ATTR) is a rare multisystemic disease involving the peripheral nervous system and heart. Autonomic and small fiber involvement is one of the hallmarks of ATTR, and many tools have been proposed to assess this aspect. Aim: The aim of this study was to investigate cutaneous and mixed nerve silent periods (CSP and MnSP) as instruments for small fiber assessment. Methods: A total of 21 ATTR patients, 20 healthy controls, and 18 asymptomatic carriers underwent a sensory conduction study from the right sural and nondominant ulnar nerves. A motor conduction study from the right deep peroneal and non-dominant ulnar nerves, with their F waves, CSPs, and MnSPs, was performed. Results: The amplitudes of the sural and ulnar sensory nerves and of the peroneal and ulnar motor nerves were reduced in ATTR patients compared to the other groups. F waves from the ulnar and peroneal nerves showed no differences between the three groups. The CSP and MnSP latency, but not amplitude, were increased in both the ulnar and peroneal nerves of ATTR patients. Conclusions: ATTR patients showed axonal involvement of large sensory and motor nerve fibers and demyelinating features of small sensory fibers

The Silent Period for Small Fiber Sensory Neuropathy Assessment in a Mixed Cohort of Transthyretin-Mediated Amyloidosis / Cambieri, Chiara; Libonati, Laura; Moret, Federica; Tartaglia, Giorgio; Garibaldi, Matteo; Chimenti, Cristina; Inghilleri, Maurizio; Ceccanti, Marco. - In: BIOMEDICINES. - ISSN 2227-9059. - 10:9(2022), p. 2073. [10.3390/biomedicines10092073]

The Silent Period for Small Fiber Sensory Neuropathy Assessment in a Mixed Cohort of Transthyretin-Mediated Amyloidosis

Chiara Cambieri
Primo
;
Laura Libonati
Secondo
;
Federica Moret;Giorgio Tartaglia;Matteo Garibaldi;Cristina Chimenti;Maurizio Inghilleri
Penultimo
;
Marco Ceccanti
Ultimo
Conceptualization
2022

Abstract

Background: Transthyretin-mediated amyloidosis (ATTR) is a rare multisystemic disease involving the peripheral nervous system and heart. Autonomic and small fiber involvement is one of the hallmarks of ATTR, and many tools have been proposed to assess this aspect. Aim: The aim of this study was to investigate cutaneous and mixed nerve silent periods (CSP and MnSP) as instruments for small fiber assessment. Methods: A total of 21 ATTR patients, 20 healthy controls, and 18 asymptomatic carriers underwent a sensory conduction study from the right sural and nondominant ulnar nerves. A motor conduction study from the right deep peroneal and non-dominant ulnar nerves, with their F waves, CSPs, and MnSPs, was performed. Results: The amplitudes of the sural and ulnar sensory nerves and of the peroneal and ulnar motor nerves were reduced in ATTR patients compared to the other groups. F waves from the ulnar and peroneal nerves showed no differences between the three groups. The CSP and MnSP latency, but not amplitude, were increased in both the ulnar and peroneal nerves of ATTR patients. Conclusions: ATTR patients showed axonal involvement of large sensory and motor nerve fibers and demyelinating features of small sensory fibers
2022
transthyretin-mediated amyloidosis; cutaneous silent period; mixed nerve silent period; neurophysiology
01 Pubblicazione su rivista::01a Articolo in rivista
The Silent Period for Small Fiber Sensory Neuropathy Assessment in a Mixed Cohort of Transthyretin-Mediated Amyloidosis / Cambieri, Chiara; Libonati, Laura; Moret, Federica; Tartaglia, Giorgio; Garibaldi, Matteo; Chimenti, Cristina; Inghilleri, Maurizio; Ceccanti, Marco. - In: BIOMEDICINES. - ISSN 2227-9059. - 10:9(2022), p. 2073. [10.3390/biomedicines10092073]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1652602
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