MicroRNAs (miRNAs/miRs) also known as small noncoding RNAs have emerged as crucial regulators in the modulation of the expression of multiple target genes at post-transcriptional level. Accumulating studies have provided compelling evidence that a wide range of miRNAs constitute an integrated part of the regulatory networks of immune response. Also, miRNAs contribute to normal immune system development and function. In particular, miRNAs can tightly regulate innate immune response by targeting key signaling components of inflammatory shapes such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and type I-III interferon (IFN-I-III) pathways. Moreover, they can finely modulate distinct immune signaling pathways involved in the T and B cell development, differentiation, tolerance (central and peripheral), and function. Taking these considerations into account, this chapter aims to describe current progress in miRNA research and to describe how these small noncoding RNAs can affect different innate and adaptive immune processes.

Chapter 15 MicroRNAs and the immune system / Frasca, Federica; Scordio, Mirko; Scagnolari, Carolina. - (2022), pp. 279-305. [10.1016/B978-0-323-89774-7.00007-8].

Chapter 15 MicroRNAs and the immune system

Federica Frasca;Mirko Scordio;Carolina Scagnolari
2022

Abstract

MicroRNAs (miRNAs/miRs) also known as small noncoding RNAs have emerged as crucial regulators in the modulation of the expression of multiple target genes at post-transcriptional level. Accumulating studies have provided compelling evidence that a wide range of miRNAs constitute an integrated part of the regulatory networks of immune response. Also, miRNAs contribute to normal immune system development and function. In particular, miRNAs can tightly regulate innate immune response by targeting key signaling components of inflammatory shapes such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and type I-III interferon (IFN-I-III) pathways. Moreover, they can finely modulate distinct immune signaling pathways involved in the T and B cell development, differentiation, tolerance (central and peripheral), and function. Taking these considerations into account, this chapter aims to describe current progress in miRNA research and to describe how these small noncoding RNAs can affect different innate and adaptive immune processes.
2022
MicroRNA From Bench to Bedside
9780323897747
micrornas; immune system; innate immune response; ifns; nf-κb; isgs; jak-stat; inflammation; adaptive immunity; t cells; b cells
02 Pubblicazione su volume::02a Capitolo o Articolo
Chapter 15 MicroRNAs and the immune system / Frasca, Federica; Scordio, Mirko; Scagnolari, Carolina. - (2022), pp. 279-305. [10.1016/B978-0-323-89774-7.00007-8].
File allegati a questo prodotto
File Dimensione Formato  
Frasca_MicroRNAs-andthe-immunesystem_2022.pdf

solo gestori archivio

Note: Chapter 15
Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 1.19 MB
Formato Adobe PDF
1.19 MB Adobe PDF   Contatta l'autore

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1652068
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact