Objective: The roleofinflammatoryadipokineshasclearmechanisticeffectsinthepromotionofbothDM2 and cardiovasculardiseases(CVDs),butitisunknowntowhatextentatherosclerosis-relatedinflamma- tion mightpromotedefectsofglucosemetabolism.Thepurposeofthisstudywastotestthehypothesis that insubjectswithatheroscleroticvasculardiseaseandnopreviousmedicalrecordoftype2diabetes mellitus (DM2),thediagnosisofoccultimpairedglucoseregulation(IGR)isrelatedtotheseverityof atherosclerosis, measuredasthesingleorcombinedpresenceofanhistoryofcoronaryarterydisease (CAD), carotidatherosclerosis(Car-ATS)andperipheralarterydisease(PAD). Methods: In apopulationof551subjects(440menand111women)withaprevioushistoryofatheroscle- rosis, weinvestigatedthepresenceofIGR(includingbothimpairedglucosetoleranceandDM2).Totest the correlationbetweenconventionalandnon-conventionalriskfactorsforcardiovasculardiseaseand diabetes weusedlogisticandregressionanalysismodels. Results: IGR wasmoreprevalentinpatientswithadocumentedvasculardiseaseintwoorthreevessel districts comparedwithpatientswithonlyonesymptomaticdistrict(p = 0.016).Amongclassicriskfactors we foundthatwaistcircumferencewascorrelatedneithertoIGRnortosymptomaticvasculardisease extension. Bycontrast,adiponectinlevelwasindependentlyassociatedtovascularandglucoseregulation status (p = 0.012and p < 0.001,respectively). Conclusion: In subjectsaffectedbyatheroscleroticvasculardiseases,thepresenceofimpairedglucose regulation isassociatedtothenumberofvasculardistrictsaffectedandtoareducedadiponectinlevel.

Occult impaired glucose regulation in patients with atherosclerosis is associated to the number of affected vascular districts and inflammation

MARTELLI, Eugenio;
2010

Abstract

Objective: The roleofinflammatoryadipokineshasclearmechanisticeffectsinthepromotionofbothDM2 and cardiovasculardiseases(CVDs),butitisunknowntowhatextentatherosclerosis-relatedinflamma- tion mightpromotedefectsofglucosemetabolism.Thepurposeofthisstudywastotestthehypothesis that insubjectswithatheroscleroticvasculardiseaseandnopreviousmedicalrecordoftype2diabetes mellitus (DM2),thediagnosisofoccultimpairedglucoseregulation(IGR)isrelatedtotheseverityof atherosclerosis, measuredasthesingleorcombinedpresenceofanhistoryofcoronaryarterydisease (CAD), carotidatherosclerosis(Car-ATS)andperipheralarterydisease(PAD). Methods: In apopulationof551subjects(440menand111women)withaprevioushistoryofatheroscle- rosis, weinvestigatedthepresenceofIGR(includingbothimpairedglucosetoleranceandDM2).Totest the correlationbetweenconventionalandnon-conventionalriskfactorsforcardiovasculardiseaseand diabetes weusedlogisticandregressionanalysismodels. Results: IGR wasmoreprevalentinpatientswithadocumentedvasculardiseaseintwoorthreevessel districts comparedwithpatientswithonlyonesymptomaticdistrict(p = 0.016).Amongclassicriskfactors we foundthatwaistcircumferencewascorrelatedneithertoIGRnortosymptomaticvasculardisease extension. Bycontrast,adiponectinlevelwasindependentlyassociatedtovascularandglucoseregulation status (p = 0.012and p < 0.001,respectively). Conclusion: In subjectsaffectedbyatheroscleroticvasculardiseases,thepresenceofimpairedglucose regulation isassociatedtothenumberofvasculardistrictsaffectedandtoareducedadiponectinlevel.
File allegati a questo prodotto
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/1651979
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 15
  • ???jsp.display-item.citation.isi??? 15
social impact