OBJECTIVES: The occurrence of thrombotic events in adult patients with inflammatory bowel disease (IBD) is linked to multiple interactions between hereditary and acquired risk factors. There are few published data concerning children with iBD. The aim of this study was to investigate the presence of thromboembolic risk factors also in children with iBD. METHODS: We enrolled three groups of children: one with Crohn disease (cD), one with ulcerative colitis (Uc), and a control group of healthy subjects. For all the participants the potential thromboembolic risk was evaluated clinically and with laboratory tests. RESULTS: We studied: 30 children (25.6%) with CD, 28 (23.9%) with UC, and 59 (50.4%) healthy control subjects. Regarding Pediatric Crohn Disease Activity Index, no significant differences between thromboembolic risk factors and disease activity were detected. Instead, in the patients with UC, stratified with the Pediatric Ulcerative Colitis Activity Index, there was a statistically significant difference in serum fibrinogen levels between patients with mild and moderate/severe disease [3.8 (3.2-4.5) g/L vs 5.7 (4.8-6.2) g/L, P  < 0.0032]. serum homocysteine levels were lower in healthy controls than in CD (P = 0.176) and UC (P = 0.026). An increased level ofhomocysteine in UC with a homozygous mutation in the methylene tetrahydrofolate reductase C677T gene was also observed. CONCLUSIONS: Our study showed that children with IBD have clinical features, acquired and congenital factors that can increase thrombotic risk, similarly to adults.

Evaluation of Risk for Thromboembolic Events in Pediatric Inflammatory Bowel Disease / Dilillo, Anna; Del Giudice, Emanuela; Cucchiara, Salvatore; Viola, Franca; Mallardo, Saverio; Isoldi, Sara; Iorfida, Donatella; Bloise, Silvia; Marcellino, Alessia; Martucci, Vanessa; Sanseviero, Mariateresa; De Luca, Enrica; Protano, Carmela; Marotta, Daniela; Ventriglia, Flavia; Lubrano, Riccardo. - In: JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION. - ISSN 0277-2116. - Publish Ahead of Print:(2022). [10.1097/MPG.0000000000003398]

Evaluation of risk for thromboembolic events in pediatric inflammatory bowel disease

Dilillo, Anna
Co-primo
;
Del Giudice, Emanuela
Co-primo
;
Cucchiara, Salvatore;Viola, Franca;Mallardo, Saverio;Isoldi, Sara;Iorfida, Donatella;Bloise, Silvia;Marcellino, Alessia;Martucci, Vanessa;De Luca, Enrica;Protano, Carmela;Marotta, Daniela;Ventriglia, Flavia
Penultimo
;
Lubrano, Riccardo
Ultimo
2022

Abstract

OBJECTIVES: The occurrence of thrombotic events in adult patients with inflammatory bowel disease (IBD) is linked to multiple interactions between hereditary and acquired risk factors. There are few published data concerning children with iBD. The aim of this study was to investigate the presence of thromboembolic risk factors also in children with iBD. METHODS: We enrolled three groups of children: one with Crohn disease (cD), one with ulcerative colitis (Uc), and a control group of healthy subjects. For all the participants the potential thromboembolic risk was evaluated clinically and with laboratory tests. RESULTS: We studied: 30 children (25.6%) with CD, 28 (23.9%) with UC, and 59 (50.4%) healthy control subjects. Regarding Pediatric Crohn Disease Activity Index, no significant differences between thromboembolic risk factors and disease activity were detected. Instead, in the patients with UC, stratified with the Pediatric Ulcerative Colitis Activity Index, there was a statistically significant difference in serum fibrinogen levels between patients with mild and moderate/severe disease [3.8 (3.2-4.5) g/L vs 5.7 (4.8-6.2) g/L, P  < 0.0032]. serum homocysteine levels were lower in healthy controls than in CD (P = 0.176) and UC (P = 0.026). An increased level ofhomocysteine in UC with a homozygous mutation in the methylene tetrahydrofolate reductase C677T gene was also observed. CONCLUSIONS: Our study showed that children with IBD have clinical features, acquired and congenital factors that can increase thrombotic risk, similarly to adults.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11573/1651572
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