Acute myeloid leukemia (AML) is a hematological malignancy originating from defective hematopoietic stem cells in the bone marrow. In spite of the recent approval of several molecular targeted therapies for AML treatment, disease recurrence remains an issue. Interestingly, increasing evidence has pointed out the relevance of bone marrow (BM) niche remodeling during leukemia onset and progression. Complex crosstalk between AML cells and microenvironment components shapes the leukemic BM niche, consequently affecting therapy responsiveness. Notably, circular RNAs are a new class of RNAs found to be relevant in AML progression and chemoresistance. In this review, we provided an overview of AML-driven niche remodeling. In particular, we analyzed the role of circRNAs and their possible contribution to cell–cell communication within the leukemic BM microenvironment. Understanding these mechanisms will help develop a more effective treatment for AML.

Circular RNAs activity in the leukemic bone marrow microenvironment / Liccardo, F.; Iaiza, A.; Sniegocka, M.; Masciarelli, S.; Fazi, F.. - In: NON-CODING RNA. - ISSN 2311-553X. - 8:4(2022), pp. 1-14. [10.3390/ncrna8040050]

Circular RNAs activity in the leukemic bone marrow microenvironment

Liccardo F.;Iaiza A.;Sniegocka M.;Masciarelli S.;Fazi F.
2022

Abstract

Acute myeloid leukemia (AML) is a hematological malignancy originating from defective hematopoietic stem cells in the bone marrow. In spite of the recent approval of several molecular targeted therapies for AML treatment, disease recurrence remains an issue. Interestingly, increasing evidence has pointed out the relevance of bone marrow (BM) niche remodeling during leukemia onset and progression. Complex crosstalk between AML cells and microenvironment components shapes the leukemic BM niche, consequently affecting therapy responsiveness. Notably, circular RNAs are a new class of RNAs found to be relevant in AML progression and chemoresistance. In this review, we provided an overview of AML-driven niche remodeling. In particular, we analyzed the role of circRNAs and their possible contribution to cell–cell communication within the leukemic BM microenvironment. Understanding these mechanisms will help develop a more effective treatment for AML.
2022
acute myeloid leukemia; bone marrow niche; circRNA; hematopoietic stem cell; non-coding RNA; therapy resistance; tumor microenvironment
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Circular RNAs activity in the leukemic bone marrow microenvironment / Liccardo, F.; Iaiza, A.; Sniegocka, M.; Masciarelli, S.; Fazi, F.. - In: NON-CODING RNA. - ISSN 2311-553X. - 8:4(2022), pp. 1-14. [10.3390/ncrna8040050]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1651452
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