: The spectrum of kidney involvement in systemic sclerosis (SSc) includes scleroderma renal crisis, widely recognized as the most severe renal-vascular complication, but also several forms of chronic renal vasculopathy and reduced renal function are complications of scleroderma. Scleroderma renal crisis, myeloperoxidase-antineutrophil cytoplasmic antibody associated glomerulonephritis, penicillamine-associated renal disease, abnormal urinalysis, alteration of vascular endothelial markers, scleroderma associated-vasculopathy with abnormal renal resistance indices and cardiorenal syndromes type 5 were also reported in SSc patients. A frequent form of renal involvement in SSc patients is a subclinical renal vasculopathy, characterized by vascular damage and normal renal function. Indeed, asymptomatic renal changes, expressed by increase of intrarenal stiffness, are often non-progressive in SSc patients but can lead to a reduction in renal functional reserve. The purpose of this review is to provide an assessment of kidney involvement in SSc, from SRC to subclinical renal vasculopathy.

Assessment of kidney involvement in systemic sclerosis: from scleroderma renal crisis to subclinical renal vasculopathy / Gigante, Antonietta; Leodori, Giorgia; Pellicano, Chiara; Villa, Annalisa; Rosato, Edoardo. - In: THE AMERICAN JOURNAL OF THE MEDICAL SCIENCES. - ISSN 0002-9629. - (2022). [10.1016/j.amjms.2022.02.014]

Assessment of kidney involvement in systemic sclerosis: from scleroderma renal crisis to subclinical renal vasculopathy

Antonietta Gigante
Membro del Collaboration Group
;
Giorgia Leodori
Membro del Collaboration Group
;
Chiara Pellicano
Membro del Collaboration Group
;
Annalisa Villa
Membro del Collaboration Group
;
Edoardo Rosato
Membro del Collaboration Group
2022

Abstract

: The spectrum of kidney involvement in systemic sclerosis (SSc) includes scleroderma renal crisis, widely recognized as the most severe renal-vascular complication, but also several forms of chronic renal vasculopathy and reduced renal function are complications of scleroderma. Scleroderma renal crisis, myeloperoxidase-antineutrophil cytoplasmic antibody associated glomerulonephritis, penicillamine-associated renal disease, abnormal urinalysis, alteration of vascular endothelial markers, scleroderma associated-vasculopathy with abnormal renal resistance indices and cardiorenal syndromes type 5 were also reported in SSc patients. A frequent form of renal involvement in SSc patients is a subclinical renal vasculopathy, characterized by vascular damage and normal renal function. Indeed, asymptomatic renal changes, expressed by increase of intrarenal stiffness, are often non-progressive in SSc patients but can lead to a reduction in renal functional reserve. The purpose of this review is to provide an assessment of kidney involvement in SSc, from SRC to subclinical renal vasculopathy.
2022
Systemic sclerosis; chronic kidney disease; renal Doppler ultrasonography; renal vasculopathy
01 Pubblicazione su rivista::01a Articolo in rivista
Assessment of kidney involvement in systemic sclerosis: from scleroderma renal crisis to subclinical renal vasculopathy / Gigante, Antonietta; Leodori, Giorgia; Pellicano, Chiara; Villa, Annalisa; Rosato, Edoardo. - In: THE AMERICAN JOURNAL OF THE MEDICAL SCIENCES. - ISSN 0002-9629. - (2022). [10.1016/j.amjms.2022.02.014]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1651314
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