Background: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV2)-related pneumonia is associated with venous and arterial thrombosis . Aim of the study was to find-out a new score for predicting thrombosis in patients with SARS-CoV-2. Methods: We included a cohort of 674 patients affected by SARS-CoV-2, not requiring intensive care units, and followed-up during the hospitalization until discharge. Routinary analyses performed at in-hospital admission included also serum albumin and D-dimer while arterial and venous thromboses were the end-points of the study. Results: During the follow-up thrombotic events 110 were registered; patients with thrombotic events were older and had lower albumin and higher D-dimer, compared to thrombotic event-free ones. On multivariable logistic regression with step by stepwise procedure age, serum albumin, D-dimer, were independently associated with thrombotic events. The linear combination of age, D-dimer, albumin allowed to build-up the ADA score, whose AUC was 0.752 (95% CI, 0.708-0.795). ADA score was internally validated by bootstrap sampling procedure giving an AUC of 0.752 (95% CI: 0.708 - 0.794). Conclusions: Combination of age, D-dimer, albumin in the ADA score allows identifying SARS-CoV-2 patients at higher risk of thrombotic events.

THE ADA (AGE-D-DIMER-ALBUMIN) SCORE TO PREDICT THROMBOSIS IN SARS-CoV-2 / Violi, Francesco; Pignatelli, Pasquale; Vestri, Annarita; Spagnoli, Alessandra; Cipollone, Francesco; Ceccarelli, Giancarlo; Oliva, Alessandra; Amitrano, Maria; Pirro, Matteo; Taliani, Gloria; Cangemi, Roberto; Lichtner, Miriam; Pugliese, Francesco; Falcone, Marco; Venditti, Mario; Mastroianni, Claudio Maria; D'Agostino, Fausto; Felice Eugenio, Agrò; Alessia, Mattei; Loredana, Tibullo; Maria Grazia, Nunziata; Valeria, Iorio; Natalia, Iuliano; Sara, Mangiacapra; Mariangela, Raimondo; Mariangela, Atteno; Ferri, Claudio; Davide, Grassi; Giovambattista, Desideri; Stefano, Abballe; Serena, Dell’Isola; Rocco, Monica; Alampi, Daniela; Cosmo, Del Borgo; Vanessa, Bianconi; Massimo Raffaele, Mannarino; Filippo, Figorilli; Maggio, Enrico; Fino, Pasquale; Loffredo, Lorenzo. - In: THROMBOSIS AND HAEMOSTASIS. - ISSN 0340-6245. - (2022). [10.1055/a-1788-7592]

THE ADA (AGE-D-DIMER-ALBUMIN) SCORE TO PREDICT THROMBOSIS IN SARS-CoV-2

Violi, Francesco;Pignatelli, Pasquale;Spagnoli, Alessandra;Cipollone, Francesco;Ceccarelli, Giancarlo;Oliva, Alessandra;Taliani, Gloria;Cangemi, Roberto;Lichtner, Miriam;Pugliese, Francesco;Falcone, Marco;Venditti, Mario;Mastroianni, Claudio Maria;Fausto, D’Agostino;Claudio, Ferri;Monica, Rocco;Daniela, Alampi;Maggio, Enrico;Pasquale, Fino;Loffredo, Lorenzo
2022

Abstract

Background: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV2)-related pneumonia is associated with venous and arterial thrombosis . Aim of the study was to find-out a new score for predicting thrombosis in patients with SARS-CoV-2. Methods: We included a cohort of 674 patients affected by SARS-CoV-2, not requiring intensive care units, and followed-up during the hospitalization until discharge. Routinary analyses performed at in-hospital admission included also serum albumin and D-dimer while arterial and venous thromboses were the end-points of the study. Results: During the follow-up thrombotic events 110 were registered; patients with thrombotic events were older and had lower albumin and higher D-dimer, compared to thrombotic event-free ones. On multivariable logistic regression with step by stepwise procedure age, serum albumin, D-dimer, were independently associated with thrombotic events. The linear combination of age, D-dimer, albumin allowed to build-up the ADA score, whose AUC was 0.752 (95% CI, 0.708-0.795). ADA score was internally validated by bootstrap sampling procedure giving an AUC of 0.752 (95% CI: 0.708 - 0.794). Conclusions: Combination of age, D-dimer, albumin in the ADA score allows identifying SARS-CoV-2 patients at higher risk of thrombotic events.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1646525
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