Mitochondrial ATPase 6,8 Associated with Brain Tumours in Patients Compared to Adjacent Normal Brain Cells

Abstract | Background: Brain cancer is considered one of the most prevalent types of cancer in the world. Primary brain tumours consist of two types. Studies provide some deficiencies in mitochondrial functions that could cause different genetic. Objective: This study aimed to determine the association of ATPase 6,8 alterations of brain tumour cells in comparison with the adjacent healthy tissue cells. Methods: A group of patients was examined, and their disease was identified during precise examinations. These persons were sampled for their affected brain tissues, and these were compared with their adjacent healthy cells. Besides, the populations of 300 healthy controls were selected as the control. The DNA of the brain tumour cells was extracted and analysed using sequencing methods. Result: After the sequence analysis, T8473C, G8584A, A8701G, A8730G and A8860G variants were found—all of them had been reported in other diseases. Also, they were observed in patients with brain tumours, as compared with the adjacent normal tissues. Discussion: The A8860G variant was one of the most prevalent polymorphisms between all these alterations in brain cancer. It seems that the ATPase 6 subunit is more prone to brain cancer. The analysis shows that amongst all the five variants determined in this research, the T8473C, G8584A and A8730G variants—with the p value<0.05—were considered to affect brain tumours.