Identification of Single Nucleotide Polymorphisms as Markers of Genetic Susceptibility for Alopecia Areata Disease Risk

Abstract | Background: Alopecia areata (AA) is an autoimmune disease, leading to disfiguring hair loss that susceptibility loci and the genetic basis of AA have been largely unknown. Objective: The aim of this study was the scrutiny the susceptible genes of Alopecia areata amongst patients and healthy adult in Iranian populations. Methods: four variants polymorphisms (rs1701704, rs10760706, rs9275572, rs694739) were studied by Tetra Arms PCR, Sequencing methods in 200 Iranian healthy adult blood donors and 200 patients with Alopecia Areata (AA). Results: Results were showed that 4 SNPs had P-values <0.05 for association with Alopecia areata. 3 of 4 SNPs, was demonstrated significant association in analyses 100 AT/AU cases versus 100 AA, which is localised in IKZF4, STX17, PRDX5, HLA-DQB1 (rs1701704, rs10760706, rs694739 and rs9275572 respectively). Conclusions: In this study, 3 of 4 SNP-associated loci were associated significantly with association with the development of Alopecia areata. In another word, the presence of them may be a contributing factor for prognosis of the development of the disease to Totalis and Universalis.