AIMS: Systemic inflammatory response syndrome (SIRS) could affect mortality after transcatheter aortic valve implantation (TAVI) up to 12 months of follow-up. The aim of this study was to evaluate the prevalence of SIRS after TAVI and its impact on all-cause mortality up to 24 months follow-up. METHODS: We retrospectively enrolled 132 patients with symptomatic severe aortic stenosis undergoing TAVI. SIRS development during the first 72 h after the intervention was evaluated. Other postoperative complications were defined according to the Valve Academic Research Consortium 2 (VARC2). All patients underwent follow-up at 30 days and 24 months. Endpoints were 30-days and 24-months mortality. RESULTS: Post-TAVI SIRS developed in 27 patients (20%). At 30-day follow-up, all-cause death occurred in 10 (8%) patients and SIRS occurred more frequently in patients with adverse short-term outcome (60 vs. 17%; P = 0.001). Twenty-four months all-cause death occurred in 25 (19%) patients. SIRS resulted as an independent predictor of long-term outcome [hazard ratio 3.7; 95% confidence interval (95% CI) 1.5-9; P = 0.004], along with major vascular complications (hazard ratio 4; 95% CI 1.6-9.9; P = 0.003), relevant bleedings (hazard ratio 6.4; 95% CI 1.5-28; P = 0.013) and baseline pulmonary hypertension (hazard ratio 2.4; 95% CI 1.05-5.6; P = 0.039). CONCLUSION: Postoperative SIRS was more frequent in patients who died at 30 days follow-up. Moreover, SIRS resulted as a predictor of 24-month mortality along with vascular complications, relevant bleedings and baseline pulmonary hypertension.

Prognostic value of systemic inflammatory response syndrome after transcatheter aortic valve implantation / Monosilio, S.; Filomena, D.; Cimino, S.; Birtolo, L. I.; Tocci, M.; Mancone, M.; Sardella, G.; Fedele, F.; Maestrini, V.; Agati, L.. - In: JOURNAL OF CARDIOVASCULAR MEDICINE. - ISSN 1558-2035. - 23:6(2022), pp. 394-398. [10.2459/JCM.0000000000001309]

Prognostic value of systemic inflammatory response syndrome after transcatheter aortic valve implantation

Monosilio S.;Filomena D.;Cimino S.;Birtolo L. I.;Tocci M.;Mancone M.;Sardella G.;Fedele F.;Maestrini V.;Agati L.
2022

Abstract

AIMS: Systemic inflammatory response syndrome (SIRS) could affect mortality after transcatheter aortic valve implantation (TAVI) up to 12 months of follow-up. The aim of this study was to evaluate the prevalence of SIRS after TAVI and its impact on all-cause mortality up to 24 months follow-up. METHODS: We retrospectively enrolled 132 patients with symptomatic severe aortic stenosis undergoing TAVI. SIRS development during the first 72 h after the intervention was evaluated. Other postoperative complications were defined according to the Valve Academic Research Consortium 2 (VARC2). All patients underwent follow-up at 30 days and 24 months. Endpoints were 30-days and 24-months mortality. RESULTS: Post-TAVI SIRS developed in 27 patients (20%). At 30-day follow-up, all-cause death occurred in 10 (8%) patients and SIRS occurred more frequently in patients with adverse short-term outcome (60 vs. 17%; P = 0.001). Twenty-four months all-cause death occurred in 25 (19%) patients. SIRS resulted as an independent predictor of long-term outcome [hazard ratio 3.7; 95% confidence interval (95% CI) 1.5-9; P = 0.004], along with major vascular complications (hazard ratio 4; 95% CI 1.6-9.9; P = 0.003), relevant bleedings (hazard ratio 6.4; 95% CI 1.5-28; P = 0.013) and baseline pulmonary hypertension (hazard ratio 2.4; 95% CI 1.05-5.6; P = 0.039). CONCLUSION: Postoperative SIRS was more frequent in patients who died at 30 days follow-up. Moreover, SIRS resulted as a predictor of 24-month mortality along with vascular complications, relevant bleedings and baseline pulmonary hypertension.
2022
aortic stenosis; inflammation; systemic inflammatory response syndrome; transcatheter aortic valve implantation; Humans; Prognosis; Retrospective Studies; Systemic Inflammatory Response Syndrome; Aortic Valve Stenosis; Hypertension, Pulmonary; Transcatheter Aortic Valve Replacement
01 Pubblicazione su rivista::01a Articolo in rivista
Prognostic value of systemic inflammatory response syndrome after transcatheter aortic valve implantation / Monosilio, S.; Filomena, D.; Cimino, S.; Birtolo, L. I.; Tocci, M.; Mancone, M.; Sardella, G.; Fedele, F.; Maestrini, V.; Agati, L.. - In: JOURNAL OF CARDIOVASCULAR MEDICINE. - ISSN 1558-2035. - 23:6(2022), pp. 394-398. [10.2459/JCM.0000000000001309]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1645178
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