It has been widely demonstrated that endocrine disruptors play a central role in various physiopathological processes of human health. In the literature, various carcinogenic processes have been associated with endocrine disruptors. A review of the molecular mechanisms underlying the interaction between endocrine disruptors and the endometrial cancer has been poorly developed. A systematic review was performed using PubMed® /MEDLINE. A total of 25 in vivo and in vitro works were selected. Numerous endocrine disruptors were analyzed. The most relevant results showed how Bisphenol A (BPA) interacts with the carcinogenesis process on several levels. It has been demonstrated how BPA can interact with hormonal receptors and with different transcription proliferative and antiproliferative factors. Furthermore, the effect of Polycyclic aromatic hydrocarbons on Aryl hydrocarbon receptors was investigated, and the role of flame retardants in promoting proliferation and metastasis was confirmed. The results obtained demonstrate how the mechanisms of action of endocrine disruptors are manifold in the pathophysiology of endometrial cancer, acting on different levels of the cancerogenesis process.

Endocrine Disruptors and Endometrial Cancer. Molecular Mechanisms of Action and Clinical Implications, A Systematic Review / Caserta, D.; De Marco, M. P.; Besharat, RAAD ARIS; Costanzi, F.. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1661-6596. - 23:6(2022), pp. 1-11. [10.3390/ijms23062956]

Endocrine Disruptors and Endometrial Cancer. Molecular Mechanisms of Action and Clinical Implications, A Systematic Review

Caserta D.;De Marco M. P.;Besharat Raad Aris;Costanzi F.
2022

Abstract

It has been widely demonstrated that endocrine disruptors play a central role in various physiopathological processes of human health. In the literature, various carcinogenic processes have been associated with endocrine disruptors. A review of the molecular mechanisms underlying the interaction between endocrine disruptors and the endometrial cancer has been poorly developed. A systematic review was performed using PubMed® /MEDLINE. A total of 25 in vivo and in vitro works were selected. Numerous endocrine disruptors were analyzed. The most relevant results showed how Bisphenol A (BPA) interacts with the carcinogenesis process on several levels. It has been demonstrated how BPA can interact with hormonal receptors and with different transcription proliferative and antiproliferative factors. Furthermore, the effect of Polycyclic aromatic hydrocarbons on Aryl hydrocarbon receptors was investigated, and the role of flame retardants in promoting proliferation and metastasis was confirmed. The results obtained demonstrate how the mechanisms of action of endocrine disruptors are manifold in the pathophysiology of endometrial cancer, acting on different levels of the cancerogenesis process.
2022
alkylphenol ethoxylates; bisphenol a; cadmium; endocrine disruptors; endometrial cancer; flame retards; mycotoxins; organoclorurate; polycyclic aromatic; benzhydryl compounds; carcinogenesis; female; humans; receptors; aryl hydrocarbon; endocrine disruptors; endometrial neoplasms; polycyclic aromatic hydrocarbons
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Endocrine Disruptors and Endometrial Cancer. Molecular Mechanisms of Action and Clinical Implications, A Systematic Review / Caserta, D.; De Marco, M. P.; Besharat, RAAD ARIS; Costanzi, F.. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1661-6596. - 23:6(2022), pp. 1-11. [10.3390/ijms23062956]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1644235
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