Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder char-acterized by inappropriate levels of attention, hyperactivity, and impulsivity that interfere with individual functioning. The international guidelines recommend targeting ADHD-related neuro-chemical brain abnormalities by intervening via drug treatment, such as methylphenidate (MPH), as first choice. Drug treatments are usually associated with a huge amount of cost for families and the healthcare system, suspension for low compliance, poor long-term efficacy, and side effects. Transcranial direct current stimulation (tDCS) has been suggested as a possible noninvasive means to safely manipulate brain activity and, in turn, improve behavior and cognition in developmental ages. Several studies have shown that tDCS has the potential to improve ADHD-related cognitive deficits, but the effect of tDCS compared with MPH has never been evaluated. The aim of the present within-subject, sham-controlled, randomized proof-of-concept study is to demonstrate the positive effect of one-session anodal tDCS analogous to the MPH drug on inhibitory control and working memory in children and adolescents with ADHD. We strongly believe that this study protocol will serve to accelerate research into low-cost, drug-free, feasible interventions for ADHD.

Comparing the Effect of Methylphenidate and Anodal tDCS on Inhibitory Control and Working-Memory in Children and Adolescents with Attention Deficit/Hyperactivity Disorder: A Study Protocol for a Randomized, within-Subject Trial / D'Aiello, B.; Battisti, A.; Lazzaro, G.; Pani, P.; De Rossi, P.; Di Vara, S.; Pretelli, I.; Costanzo, F.; Vicari, S.; Menghini, D.. - In: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. - ISSN 1660-4601. - 19:8(2022), pp. 1-15. [10.3390/ijerph19084575]

Comparing the Effect of Methylphenidate and Anodal tDCS on Inhibitory Control and Working-Memory in Children and Adolescents with Attention Deficit/Hyperactivity Disorder: A Study Protocol for a Randomized, within-Subject Trial

Pani P.;
2022

Abstract

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder char-acterized by inappropriate levels of attention, hyperactivity, and impulsivity that interfere with individual functioning. The international guidelines recommend targeting ADHD-related neuro-chemical brain abnormalities by intervening via drug treatment, such as methylphenidate (MPH), as first choice. Drug treatments are usually associated with a huge amount of cost for families and the healthcare system, suspension for low compliance, poor long-term efficacy, and side effects. Transcranial direct current stimulation (tDCS) has been suggested as a possible noninvasive means to safely manipulate brain activity and, in turn, improve behavior and cognition in developmental ages. Several studies have shown that tDCS has the potential to improve ADHD-related cognitive deficits, but the effect of tDCS compared with MPH has never been evaluated. The aim of the present within-subject, sham-controlled, randomized proof-of-concept study is to demonstrate the positive effect of one-session anodal tDCS analogous to the MPH drug on inhibitory control and working memory in children and adolescents with ADHD. We strongly believe that this study protocol will serve to accelerate research into low-cost, drug-free, feasible interventions for ADHD.
2022
drug treatments; evidence-based medicine; executive functions; MPH; transcranial direct current stimulation; Adolescent; Child; Humans; Memory, Short-Term; Prefrontal Cortex; Randomized Controlled Trials as Topic; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Methylphenidate; Transcranial Direct Current Stimulation
01 Pubblicazione su rivista::01a Articolo in rivista
Comparing the Effect of Methylphenidate and Anodal tDCS on Inhibitory Control and Working-Memory in Children and Adolescents with Attention Deficit/Hyperactivity Disorder: A Study Protocol for a Randomized, within-Subject Trial / D'Aiello, B.; Battisti, A.; Lazzaro, G.; Pani, P.; De Rossi, P.; Di Vara, S.; Pretelli, I.; Costanzo, F.; Vicari, S.; Menghini, D.. - In: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. - ISSN 1660-4601. - 19:8(2022), pp. 1-15. [10.3390/ijerph19084575]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1644167
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