Background: Hypertriglyceridemia has been identified as a risk factor for diabetic neuropathy. Objective: Patients with hypertriglyceridemia underwent assessment of neuropathy and corneal confocal microscopy. Methods: 24 patients with severe hypertriglyceridemia defined as a triglyceride level more than 5.5 mmol/L (485 mg/dL) with no history of diabetes and 19 age-matched controls underwent assessment of HbA1c, blood pressure, fasting lipid profile, neuropathy disability score (NDS) and corneal confocal microscopy (CCM). Results: Patients with hypertriglyceridemia had a significantly higher NDS (P<0.001) and lower CNFD (no./mm2) (27.1 [25.0-29.9] Vs 35.9 [31.2-40.6], p<0.001), CNBD (no./mm2) (55.4±22.3 Vs 91.6±30.8, p<0.001), CNFL (mm/mm2) (19.2±4.3 Vs 26.7±4.4, p<0.001) and IWL (mm/mm2) (24.3±6.9 Vs 36.6±10.0, p<0.001) compared to control subjects. In subjects with hypertriglyceridemia serum triglyceride levels correlated with CNFD (rho= -0.473, p=0.002), CNBD (rho= -0.341, p=0.043), CNFL (rho= -0.446, p=0.006) and IWL (rho= -0.408, p=0.034), no correlation was found between triglycerides and CCM parameters in subjects without hypertriglyceridemia. Subjects with metabolic syndrome had a lower CNFD (32.3 [29.2-37.5] Vs 27.1 [20.8-30.2] no./mm2, p=0.003), CNBD (20.1±6.0 Vs 23.9±5.3 no./mm2, p=0.036), CNFL (57.7±26.9 Vs 79.2±32.6 mm/mm2, p=0.037) and IWL (25.4±7.1 Vs 32.9±11.2 mm/mm2, p=0.036) compared to subjects without metabolic syndrome. Conclusion: Hypertriglyceridemia and metabolic syndrome are associated with small nerve fibre damage and clinical neuropathy. Elevated serum triglycerides may be a potential therapeutic target for the treatment of peripheral neuropathy.

Corneal confocal microscopy identifies small nerve fibre damage in patients with hypertriglyceridemia / D'Onofrio, L.; Ferdousi, M.; Kalteniece, A.; Iqbal, Z.; Petropoulos, I. N.; Ponirakis, G.; Buzzetti, R.; Malik, R. A.; Soran, H.. - In: JOURNAL OF CLINICAL LIPIDOLOGY. - ISSN 1933-2874. - 16:4(2022), pp. 1-9. [10.1016/j.jacl.2022.04.006]

Corneal confocal microscopy identifies small nerve fibre damage in patients with hypertriglyceridemia

D'Onofrio L.;Buzzetti R.;
2022

Abstract

Background: Hypertriglyceridemia has been identified as a risk factor for diabetic neuropathy. Objective: Patients with hypertriglyceridemia underwent assessment of neuropathy and corneal confocal microscopy. Methods: 24 patients with severe hypertriglyceridemia defined as a triglyceride level more than 5.5 mmol/L (485 mg/dL) with no history of diabetes and 19 age-matched controls underwent assessment of HbA1c, blood pressure, fasting lipid profile, neuropathy disability score (NDS) and corneal confocal microscopy (CCM). Results: Patients with hypertriglyceridemia had a significantly higher NDS (P<0.001) and lower CNFD (no./mm2) (27.1 [25.0-29.9] Vs 35.9 [31.2-40.6], p<0.001), CNBD (no./mm2) (55.4±22.3 Vs 91.6±30.8, p<0.001), CNFL (mm/mm2) (19.2±4.3 Vs 26.7±4.4, p<0.001) and IWL (mm/mm2) (24.3±6.9 Vs 36.6±10.0, p<0.001) compared to control subjects. In subjects with hypertriglyceridemia serum triglyceride levels correlated with CNFD (rho= -0.473, p=0.002), CNBD (rho= -0.341, p=0.043), CNFL (rho= -0.446, p=0.006) and IWL (rho= -0.408, p=0.034), no correlation was found between triglycerides and CCM parameters in subjects without hypertriglyceridemia. Subjects with metabolic syndrome had a lower CNFD (32.3 [29.2-37.5] Vs 27.1 [20.8-30.2] no./mm2, p=0.003), CNBD (20.1±6.0 Vs 23.9±5.3 no./mm2, p=0.036), CNFL (57.7±26.9 Vs 79.2±32.6 mm/mm2, p=0.037) and IWL (25.4±7.1 Vs 32.9±11.2 mm/mm2, p=0.036) compared to subjects without metabolic syndrome. Conclusion: Hypertriglyceridemia and metabolic syndrome are associated with small nerve fibre damage and clinical neuropathy. Elevated serum triglycerides may be a potential therapeutic target for the treatment of peripheral neuropathy.
2022
corneal confocal microscopy; metabolic syndrome; neuropathy; small fibre neuropathy; triglycerides
01 Pubblicazione su rivista::01a Articolo in rivista
Corneal confocal microscopy identifies small nerve fibre damage in patients with hypertriglyceridemia / D'Onofrio, L.; Ferdousi, M.; Kalteniece, A.; Iqbal, Z.; Petropoulos, I. N.; Ponirakis, G.; Buzzetti, R.; Malik, R. A.; Soran, H.. - In: JOURNAL OF CLINICAL LIPIDOLOGY. - ISSN 1933-2874. - 16:4(2022), pp. 1-9. [10.1016/j.jacl.2022.04.006]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1643701
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