We investigated the clinical significance of tumour-infiltrating FOXP3-positive regulatory Tcells (Tregs) in radically resected (R0) gastric cancer. From a single-institution database,tumors of 110 patients who underwent R0 resection for stage II–III disease were studiedfor FOXP3-positive Tregs by immunohistochemistry. The observed median number ofFOXP3-positive Tregs was used as the cut-point in analyses (<6 versus P6 count). Tregswere significantly higher in gastric carcinomas than in normal tissue (P = 0.0001). TregscountP6 was significantly associated with vascular/lymphatic/perineural invasion (VELIPI)in the tumour (P = 0.03). Multivariate analysis showed association between adverse relapsefreesurvival and grading 3, stage III, VELIPI and Tregs count P6 (P = 0.02). Adverse overallsurvival was associated with grading 3, stage III, VELIPI and Tregs count P6 (P = 0.006).FOXP3-positive Tregs may be a novel marker for identifying high-risk gastric cancerpatients. Present findings deserve additional investigation as Tregs may also represent aninnovative therapeutic target.
Intratumoural FOXP3-positive regulatory T cells are associated with adverse prognosis in radically resected gastric cancer / Perrone, G., Ruffini, P.a., Catalano, V., Spino, C., Santini, D., Muretto, P., Spoto, C., Zingaretti, C., Sisti, V., Alessandroni, P., Giordani, P., Cicetti, A., D'Emidio, S., Morini, S., Ruzzo, A., Magnani, M., Tonini, G., Rabitti, C., Graziano, F.. - In: EUROPEAN JOURNAL OF CANCER. - ISSN 0959-8049. - 44:13(2008), pp. 1875-1882. [10.1016/j.ejca.2008.05.017]
Intratumoural FOXP3-positive regulatory T cells are associated with adverse prognosis in radically resected gastric cancer
PERRONE G;SANTINI D;
2008
Abstract
We investigated the clinical significance of tumour-infiltrating FOXP3-positive regulatory Tcells (Tregs) in radically resected (R0) gastric cancer. From a single-institution database,tumors of 110 patients who underwent R0 resection for stage II–III disease were studiedfor FOXP3-positive Tregs by immunohistochemistry. The observed median number ofFOXP3-positive Tregs was used as the cut-point in analyses (<6 versus P6 count). Tregswere significantly higher in gastric carcinomas than in normal tissue (P = 0.0001). TregscountP6 was significantly associated with vascular/lymphatic/perineural invasion (VELIPI)in the tumour (P = 0.03). Multivariate analysis showed association between adverse relapsefreesurvival and grading 3, stage III, VELIPI and Tregs count P6 (P = 0.02). Adverse overallsurvival was associated with grading 3, stage III, VELIPI and Tregs count P6 (P = 0.006).FOXP3-positive Tregs may be a novel marker for identifying high-risk gastric cancerpatients. Present findings deserve additional investigation as Tregs may also represent aninnovative therapeutic target.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
