Renal cell carcinoma represents approximately 3% of adult malignancies and 90-95% of neoplasms arising from the kidney. Many agents that target angiogenesis (e. g., sunitinib, sorafenib, bevacizumab and pazopanib) and mTOR-targeted therapy (e. g., temsirolimus and everolimus) have been approved as first-line agents. The choice of the most suitable treatment for advanced renal cell carcinoma depends on the definition of risk. In this article, we reviewed the scientific literature identifying predictive factors on the activity/efficacy of a specific therapy.
Predictive factors of response to treatment in patients with metastatic renal cell carcinoma: new evidence / Tonini, G; Fratto, Me; Imperatori, M; Pantano, F; Vincenzi, B; Santini, D. - In: EXPERT REVIEW OF ANTICANCER THERAPY. - ISSN 1473-7140. - 11:6(2011), pp. 921-930. [10.1586/ERA.11.63]
Predictive factors of response to treatment in patients with metastatic renal cell carcinoma: new evidence
Santini D
2011
Abstract
Renal cell carcinoma represents approximately 3% of adult malignancies and 90-95% of neoplasms arising from the kidney. Many agents that target angiogenesis (e. g., sunitinib, sorafenib, bevacizumab and pazopanib) and mTOR-targeted therapy (e. g., temsirolimus and everolimus) have been approved as first-line agents. The choice of the most suitable treatment for advanced renal cell carcinoma depends on the definition of risk. In this article, we reviewed the scientific literature identifying predictive factors on the activity/efficacy of a specific therapy.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
