Optical biosensing systems are commonly developed assembling a source, a light–sample interaction area, and a detector as distinct stand-alone elements. We present a compact, inexpensive, and easy-to-use glass chip that monolithically integrates both the interaction and detection elements in a 1 cm2 overall surface. The device working principle is based on evanescent wavelight interaction with the complex refractive index of a liquid mixture, being the index influenced by the mixture’s physical and chemical features. We describe the manufacture of a prototype able to perform investigations on food quality and subsequent tests on the detection of fat content in milk. Theoretical investigations are reported as well as measurements performed on samples in the green spectrum. A sensitivity of about 139 fA/(g/dL) and a limit of detection of 14 ppm have been achieved, better than those of current commercial devices.

Evanescent waveguide lab-on-chip for optical biosensing in food quality control / Buzzin, A.; Asquini, R.; Caputo, D.; de Cesare, G.. - In: PHOTONICS RESEARCH. - ISSN 2327-9125. - 10:6(2022), pp. 1453-1461. [10.1364/PRJ.454288]

Evanescent waveguide lab-on-chip for optical biosensing in food quality control

Buzzin A.;Asquini R.;Caputo D.;de Cesare G.
2022

Abstract

Optical biosensing systems are commonly developed assembling a source, a light–sample interaction area, and a detector as distinct stand-alone elements. We present a compact, inexpensive, and easy-to-use glass chip that monolithically integrates both the interaction and detection elements in a 1 cm2 overall surface. The device working principle is based on evanescent wavelight interaction with the complex refractive index of a liquid mixture, being the index influenced by the mixture’s physical and chemical features. We describe the manufacture of a prototype able to perform investigations on food quality and subsequent tests on the detection of fat content in milk. Theoretical investigations are reported as well as measurements performed on samples in the green spectrum. A sensitivity of about 139 fA/(g/dL) and a limit of detection of 14 ppm have been achieved, better than those of current commercial devices.
2022
lab-on-chip; optical biosensor; thin-film photosensor; polymer waveguide; food quality; milk fat detection.
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Evanescent waveguide lab-on-chip for optical biosensing in food quality control / Buzzin, A.; Asquini, R.; Caputo, D.; de Cesare, G.. - In: PHOTONICS RESEARCH. - ISSN 2327-9125. - 10:6(2022), pp. 1453-1461. [10.1364/PRJ.454288]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1640409
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