Invasion of the tunica albuginea (TA) and/or urethra are key factors in determining the feasibility of organ-preserving surgery in penile cancer (PC). Magnetic resonance imaging (MRI) appeared to be a promising technique for preoperative local staging. We performed a systematic review (SR) and pooled meta-analysis to investigate the diagnostic performance of MRI in preoperative local staging of primary PC. An SR up to May 2021 was performed according to the PRISMA statement. The diagnostic performance of MRI was evaluated according to TA invasion, urethra invasion, and pT-stage ≥ 2. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) from eligible studies were pooled and summary receiver operating charac-teristic (SROC) curves were constructed. Overall, seven qualified studies were deemed suitable. Diagnostic performance of MRI showed an accuracy of 0.89 for TA invasion (sensitivity 0.78, PPV 0.79, specificity 0.91, and NPV 0.90); an accuracy of 0.88 for urethra invasion (sensitivity 0.65, PPV 0.46, specificity 0.86, and NPV 0.93); an accuracy of 0.90 for pT ≥ 2 (sensitivity 0.86, PPV 0.84, specificity 0.70, and NPV 0.73).Currently available evidence indicates that MRI might be a one-stop shop for local staging of primary PC and play a central role with regard to conservative surgical manage-ment.

Diagnostic performance of magnetic resonance imaging for preoperative local staging of penile cancer: a systematic review and meta-analysis / Flammia, R. S.; Tufano, A.; Antonelli, L.; Bernardotto, A.; Castro Bigalli, A. A.; Tian, Z.; Smaldone, M. C.; Karakiewicz, P. I.; Panebianco, V.; Leonardo, C.. - In: APPLIED SCIENCES. - ISSN 2076-3417. - 11:15(2021). [10.3390/app11157090]

Diagnostic performance of magnetic resonance imaging for preoperative local staging of penile cancer: a systematic review and meta-analysis

Flammia R. S.
Co-primo
;
Tufano A.
Co-primo
;
Antonelli L.;Panebianco V.
Penultimo
;
Leonardo C.
Ultimo
2021

Abstract

Invasion of the tunica albuginea (TA) and/or urethra are key factors in determining the feasibility of organ-preserving surgery in penile cancer (PC). Magnetic resonance imaging (MRI) appeared to be a promising technique for preoperative local staging. We performed a systematic review (SR) and pooled meta-analysis to investigate the diagnostic performance of MRI in preoperative local staging of primary PC. An SR up to May 2021 was performed according to the PRISMA statement. The diagnostic performance of MRI was evaluated according to TA invasion, urethra invasion, and pT-stage ≥ 2. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) from eligible studies were pooled and summary receiver operating charac-teristic (SROC) curves were constructed. Overall, seven qualified studies were deemed suitable. Diagnostic performance of MRI showed an accuracy of 0.89 for TA invasion (sensitivity 0.78, PPV 0.79, specificity 0.91, and NPV 0.90); an accuracy of 0.88 for urethra invasion (sensitivity 0.65, PPV 0.46, specificity 0.86, and NPV 0.93); an accuracy of 0.90 for pT ≥ 2 (sensitivity 0.86, PPV 0.84, specificity 0.70, and NPV 0.73).Currently available evidence indicates that MRI might be a one-stop shop for local staging of primary PC and play a central role with regard to conservative surgical manage-ment.
2021
magnetic resonance imaging; organ sparing surgery; penile amputation; penile neoplasms; radical penectomy
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Diagnostic performance of magnetic resonance imaging for preoperative local staging of penile cancer: a systematic review and meta-analysis / Flammia, R. S.; Tufano, A.; Antonelli, L.; Bernardotto, A.; Castro Bigalli, A. A.; Tian, Z.; Smaldone, M. C.; Karakiewicz, P. I.; Panebianco, V.; Leonardo, C.. - In: APPLIED SCIENCES. - ISSN 2076-3417. - 11:15(2021). [10.3390/app11157090]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1639391
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