Engineered probiotics represent a cutting-edge therapy in intestinal inflammatory disease (IBD). Genetically modified bacteria have provided a new strategy to release therapeutically operative molecules in the intestine and have grown into promising new therapies for IBD. Current IBD treatments, such as corticosteroids and immunosuppressants, are associated with relevant side effects and a significant proportion of patients are dependent on these therapies, thus exposing them to the risk of relevant long-term side effects. Discovering new and effective therapeutic strategies is a worldwide goal in this research field and engineered probiotics could potentially provide a viable solution. This review aims at describing the proceeding of bacterial engineering and how genetically modified probiotics may represent a promising new biotechnological approach in IBD treatment.

Next-Generation Probiotics for Inflammatory Bowel Disease / Pesce, Marcella; Seguella, Luisa; Del Re, Alessandro; Lu, Jie; Palenca, Irene; Corpetti, Chiara; Rurgo, Sara; Sanseverino, Walter; Sarnelli, Giovanni; Esposito, Giuseppe. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 23:10(2022). [10.3390/ijms23105466]

Next-Generation Probiotics for Inflammatory Bowel Disease

Luisa Seguella
;
Alessandro Del Re;Irene Palenca;Chiara Corpetti;Giuseppe Esposito
2022

Abstract

Engineered probiotics represent a cutting-edge therapy in intestinal inflammatory disease (IBD). Genetically modified bacteria have provided a new strategy to release therapeutically operative molecules in the intestine and have grown into promising new therapies for IBD. Current IBD treatments, such as corticosteroids and immunosuppressants, are associated with relevant side effects and a significant proportion of patients are dependent on these therapies, thus exposing them to the risk of relevant long-term side effects. Discovering new and effective therapeutic strategies is a worldwide goal in this research field and engineered probiotics could potentially provide a viable solution. This review aims at describing the proceeding of bacterial engineering and how genetically modified probiotics may represent a promising new biotechnological approach in IBD treatment.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1637861
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