In this study we describe the generation and characterization of an human induced pluripotent stem cell (hiPSC) line from a long QT syndrome type 1 (LQT1) patient carrying the KCNQ1 c.940 G > A (p.Gly314Ser) mutation. This patient-specific iPSC line has been obtained by using non-integrational Sendai reprogramming method, expresses pluripotency markers and has the capacity to differentiate into the three germ layers and into spontaneously beating cardiomyocytes (iPSC-CMs).
Generation and characterization of the human induced pluripotent stem cell (hiPSC) line NCUFi001-A from a patient carrying KCNQ1 G314S mutation / Lavra, L.; Magi, F.; Ulivieri, A.; Morgante, A.; Paulis, M.; Sala, L.; Pedrazzini, M.; Polisca, P.; Rocchetti, M.; Calo, L.; Sciacchitano, S.; Salehi, L. B.. - In: STEM CELL RESEARCH. - ISSN 1873-5061. - 54:(2021). [10.1016/j.scr.2021.102418]
Generation and characterization of the human induced pluripotent stem cell (hiPSC) line NCUFi001-A from a patient carrying KCNQ1 G314S mutation
Lavra L.;Rocchetti M.;Sciacchitano S.;
2021
Abstract
In this study we describe the generation and characterization of an human induced pluripotent stem cell (hiPSC) line from a long QT syndrome type 1 (LQT1) patient carrying the KCNQ1 c.940 G > A (p.Gly314Ser) mutation. This patient-specific iPSC line has been obtained by using non-integrational Sendai reprogramming method, expresses pluripotency markers and has the capacity to differentiate into the three germ layers and into spontaneously beating cardiomyocytes (iPSC-CMs).| File | Dimensione | Formato | |
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