Background: Juvenile idiopathic arthritis (JIA) is a rheumatic condition of childhood that is frequently associated with anterior chronic uveitis. Evidence suggests that uveitis may persist up to adulthood in some cases, possibly causing severe visual impairment. Methods: We conducted a retrospective study on a series of patients aged 16 years or older with JIA-related active uveitis who were referred to the Uveitis Service of Sapienza University of Rome from 1990 to 2019 to evaluate the characteristics of ocular disease in patients with JIA-associated uveitis (JIA-U) who still exhibit uveitis in adulthood. Data on clinical features, treatment, complications and visual outcomes were collected. Results: Twenty adults (85% female; median age 23.4 ± 6.6 years, range 16–38 years) with ongoing uveitis (35 eyes) were identified. The median age at JIA onset was 6.15 ± 2.9 years (range 2–10), and uveitis onset was 8.7 ± 4.7 years (range 3–20). The patients were observed in a median follow-up of 16 ± 7.7 years (range 4–35). Fifty-seven percent of affected eyes (20 eyes) had good visual acuity (>0.4 logMAR), while eleven percent of affected eyes (4 eyes) were blind (≤20/200). Uveitis required topical steroids and mydriatic/cycloplegic in all cases. Orbital steroid injection was performed in 13 eyes. Systemic corticosteroids and biologic drugs were used in 14 patients. Conclusions: Although the visual prognosis of JIA-U has improved in recent years, persistent uveitis up to adulthood is still observed. Therefore, protracted follow-up of JIA-U patients is warranted because of the high burden of delayed visual complications.

Persistence of juvenile idiopathic arthritis-associated uveitis in adulthood: a retrospective study / Paroli, Maria Pia; Abbouda, Alessandro; Albanese, GIUSEPPE MARIA; Accorinti, Massimo; Falcione, Alessandro; Spadea, Leopoldo; Paroli, Marino. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 11:9(2022). [10.3390/jcm11092471]

Persistence of juvenile idiopathic arthritis-associated uveitis in adulthood: a retrospective study

Maria Pia Paroli
Primo
;
Alessandro Abbouda
Secondo
;
Giuseppe Albanese;Massimo Accorinti;Leopoldo Spadea
Penultimo
;
Marino Paroli
Ultimo
2022

Abstract

Background: Juvenile idiopathic arthritis (JIA) is a rheumatic condition of childhood that is frequently associated with anterior chronic uveitis. Evidence suggests that uveitis may persist up to adulthood in some cases, possibly causing severe visual impairment. Methods: We conducted a retrospective study on a series of patients aged 16 years or older with JIA-related active uveitis who were referred to the Uveitis Service of Sapienza University of Rome from 1990 to 2019 to evaluate the characteristics of ocular disease in patients with JIA-associated uveitis (JIA-U) who still exhibit uveitis in adulthood. Data on clinical features, treatment, complications and visual outcomes were collected. Results: Twenty adults (85% female; median age 23.4 ± 6.6 years, range 16–38 years) with ongoing uveitis (35 eyes) were identified. The median age at JIA onset was 6.15 ± 2.9 years (range 2–10), and uveitis onset was 8.7 ± 4.7 years (range 3–20). The patients were observed in a median follow-up of 16 ± 7.7 years (range 4–35). Fifty-seven percent of affected eyes (20 eyes) had good visual acuity (>0.4 logMAR), while eleven percent of affected eyes (4 eyes) were blind (≤20/200). Uveitis required topical steroids and mydriatic/cycloplegic in all cases. Orbital steroid injection was performed in 13 eyes. Systemic corticosteroids and biologic drugs were used in 14 patients. Conclusions: Although the visual prognosis of JIA-U has improved in recent years, persistent uveitis up to adulthood is still observed. Therefore, protracted follow-up of JIA-U patients is warranted because of the high burden of delayed visual complications.
2022
JIA-associated uveitis; JIA in adulthood; uveitis complications; uveitis treatment
01 Pubblicazione su rivista::01a Articolo in rivista
Persistence of juvenile idiopathic arthritis-associated uveitis in adulthood: a retrospective study / Paroli, Maria Pia; Abbouda, Alessandro; Albanese, GIUSEPPE MARIA; Accorinti, Massimo; Falcione, Alessandro; Spadea, Leopoldo; Paroli, Marino. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 11:9(2022). [10.3390/jcm11092471]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1633477
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