Purpose: The aim of our study was to evaluate and compare the expression of different immunohistochemical markers in Bladder Carcinomas (BC) in patients with Neurogenic Bladder (NB) and Urinary Schistosomiasis (US) infection. Materials and methods: We collected tissue samples from patients with Neurogenic Bladder and Bladder Carcinoma (NBC Group) and from patients with Urinary Schistosomiasis infection and Bladder Carcinoma (SBC Group). We compared to these two groups to control samples from resection from patients with Urinary Schistosomiasis without Bladder Carcinoma (US Group); we also investigate patients’ characteristics according to urothelial transitional cell carcinoma (TCC), and squamous cell carcinoma (SCC) histopathological differentiation. The expression of markers in all groups (CK7, CK14, CK20, FoxP3, GATA3, STAG2, CD3, CD8, Ki67, and P53) was analyzed using immunohistochemistry of tissue micro-array sections (TMA). Results: Overall, 136 patients were included in the study (n = 72 in the NBC group, n = 33 in the SBC group, and n = 31 in the US group). In the TCC subgroup, the expression of CK7, CK14, CK20, and Ki67 was significantly higher compared to US controls (p 0.002; p < 0.001; p 0.036; p < 0.001). In the SCC subgroup, the expression of CK7, CK14, and CK20 was significantly higher compared to US controls (p 0.007; p < 0.001; p 0.005). Both in TCC and SCC subgroups, no difference in the expression of any tested markers was found comparing NBC and SBC groups. In US group, a significant higher expression of STAG2 was found compared to SCC subgroup (p 0.005). Conclusion: Based on our results, the profile of immunohistochemical biomarkers’ expression in both NBC and SBC groups is similar.

Bladder carcinomas in patients with neurogenic bladder and urinary schistosomiasis. are they the same tumors? / Cancrini, F.; Michel, F.; Cussenot, O.; Alshehhi, H.; Comperat, E.; Phe, V.. - In: WORLD JOURNAL OF UROLOGY. - ISSN 0724-4983. - (2022), pp. 1-26. [10.1007/s00345-022-03941-4]

Bladder carcinomas in patients with neurogenic bladder and urinary schistosomiasis. are they the same tumors?

Cancrini F.
Writing – Review & Editing
;
2022

Abstract

Purpose: The aim of our study was to evaluate and compare the expression of different immunohistochemical markers in Bladder Carcinomas (BC) in patients with Neurogenic Bladder (NB) and Urinary Schistosomiasis (US) infection. Materials and methods: We collected tissue samples from patients with Neurogenic Bladder and Bladder Carcinoma (NBC Group) and from patients with Urinary Schistosomiasis infection and Bladder Carcinoma (SBC Group). We compared to these two groups to control samples from resection from patients with Urinary Schistosomiasis without Bladder Carcinoma (US Group); we also investigate patients’ characteristics according to urothelial transitional cell carcinoma (TCC), and squamous cell carcinoma (SCC) histopathological differentiation. The expression of markers in all groups (CK7, CK14, CK20, FoxP3, GATA3, STAG2, CD3, CD8, Ki67, and P53) was analyzed using immunohistochemistry of tissue micro-array sections (TMA). Results: Overall, 136 patients were included in the study (n = 72 in the NBC group, n = 33 in the SBC group, and n = 31 in the US group). In the TCC subgroup, the expression of CK7, CK14, CK20, and Ki67 was significantly higher compared to US controls (p 0.002; p < 0.001; p 0.036; p < 0.001). In the SCC subgroup, the expression of CK7, CK14, and CK20 was significantly higher compared to US controls (p 0.007; p < 0.001; p 0.005). Both in TCC and SCC subgroups, no difference in the expression of any tested markers was found comparing NBC and SBC groups. In US group, a significant higher expression of STAG2 was found compared to SCC subgroup (p 0.005). Conclusion: Based on our results, the profile of immunohistochemical biomarkers’ expression in both NBC and SBC groups is similar.
2022
urinary schistosomiasis; bladder carcinoma; squamous cell carcinoma; neurogenic bladder
01 Pubblicazione su rivista::01a Articolo in rivista
Bladder carcinomas in patients with neurogenic bladder and urinary schistosomiasis. are they the same tumors? / Cancrini, F.; Michel, F.; Cussenot, O.; Alshehhi, H.; Comperat, E.; Phe, V.. - In: WORLD JOURNAL OF UROLOGY. - ISSN 0724-4983. - (2022), pp. 1-26. [10.1007/s00345-022-03941-4]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1629863
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