Half of inflammatory myofibroblastic tumors (IMTs) regardless of anatomic location harbor anaplastic lymphoma kinase gene (ALK) rearrangements and overexpress anaplastic lymphoma kinase protein. The wide application of next-generation sequencing and the clinical benefit to tyrosine kinase inhibitors have opened new opportunities for investigation of ALK-negative IMTs.
Expanding the molecular characterization of thoracic inflammatory myofibroblastic tumors beyond ALK gene rearrangements / Chang, Jason C; Zhang, Lei; Drilon, Alexander E; Chi, Ping; Alaggio, Rita; Borsu, Laetitia; Benayed, Ryma; Travis, William D; Ladanyi, Marc; Antonescu, Cristina R. - In: JOURNAL OF THORACIC ONCOLOGY. - ISSN 1556-0864. - 14:5(2019), pp. 825-834. [10.1016/j.jtho.2018.12.003]
Expanding the molecular characterization of thoracic inflammatory myofibroblastic tumors beyond ALK gene rearrangements
Alaggio, Rita;
2019
Abstract
Half of inflammatory myofibroblastic tumors (IMTs) regardless of anatomic location harbor anaplastic lymphoma kinase gene (ALK) rearrangements and overexpress anaplastic lymphoma kinase protein. The wide application of next-generation sequencing and the clinical benefit to tyrosine kinase inhibitors have opened new opportunities for investigation of ALK-negative IMTs.| File | Dimensione | Formato | |
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Chang_Expanding_2019.pdf
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Note: https://www.sciencedirect.com/science/article/pii/S1556086418335123
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