Condensationof DNAhelicesintohexagonallypacked bundlesand toroidsrepresentsan intriguingexampleof functionalorganizationof biologicalmacromoleculesat thenanoscale.The condensationmodelsare basedon the uniquepolyelectrolytefeaturesof DNA, howeverherewe couldreproduceaDNA-likecondensationwithsupramolecularhelicesof smallchiral molecules,therebydemonstratingthatit is amore generalphenomenon.We showthat the bile saltsodiumdeoxycholate can formsupramolecularhelicesuponinteractionwithoppositelychargedpolyelectrolytesof homo-polymeror blockcopolymers.Athigherorder,acontrolledhexagonalpackingof the helicesintoDNA-likebundlesandtoroidscouldbe accomplished.The resultsdiscloseunknownsimilaritiesbetweencovalent and supramolecularnon-covalenthelicalpolyelectrolytes,whichinspirevisionaryideasofconstructingsupramolecularversionsof biologicalmacro-molecules.Asdrug nanocarriersthe polymer–bilesalt super-structureswouldget advantageof acomplexchiralityatmolecularandsupramolecularlevels,whoseeffecton thenanocarrierassisteddrugefficiencyis astill unexploredfascinatingissue.
Condensed Supramolecular Helices: The Twisted Sisters of DNA / Du, Guanqun; Belić, Domagoj; Del Giudice, Alessandra; Alfredsson, Viveka; Carnerup, Anna M.; Zhu, Kaizheng; Nyström, Bo; Wang, Yilin; Galantini, Luciano; Schillén, Karin. - In: ANGEWANDTE CHEMIE. - ISSN 0044-8249. - 134:4(2022). [10.1002/anie.202113279]
Condensed Supramolecular Helices: The Twisted Sisters of DNA
Del Giudice, Alessandra;Galantini, Luciano
;
2022
Abstract
Condensationof DNAhelicesintohexagonallypacked bundlesand toroidsrepresentsan intriguingexampleof functionalorganizationof biologicalmacromoleculesat thenanoscale.The condensationmodelsare basedon the uniquepolyelectrolytefeaturesof DNA, howeverherewe couldreproduceaDNA-likecondensationwithsupramolecularhelicesof smallchiral molecules,therebydemonstratingthatit is amore generalphenomenon.We showthat the bile saltsodiumdeoxycholate can formsupramolecularhelicesuponinteractionwithoppositelychargedpolyelectrolytesof homo-polymeror blockcopolymers.Athigherorder,acontrolledhexagonalpackingof the helicesintoDNA-likebundlesandtoroidscouldbe accomplished.The resultsdiscloseunknownsimilaritiesbetweencovalent and supramolecularnon-covalenthelicalpolyelectrolytes,whichinspirevisionaryideasofconstructingsupramolecularversionsof biologicalmacro-molecules.Asdrug nanocarriersthe polymer–bilesalt super-structureswouldget advantageof acomplexchiralityatmolecularandsupramolecularlevels,whoseeffecton thenanocarrierassisteddrugefficiencyis astill unexploredfascinatingissue.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
