Over recent years, great attention has been paid to the role of the complement system in the pathogenesis of age-related macular degeneration (AMD). In particular, several studies have highlighted a link between AMD development and complement dysregulation, which can probably be explained as a complement cascade hyperactivation resulting from the presence of a series of risk factors such as aging; smoking; obesity; alcohol consumption; exposure to pesticides, industrial chemicals, or pollution; and other causes of oxidative stress. This hypothesis has been mainly supported by the presence of complement mediators as constituents of drusen, representing one of the earliest and most characteristic signs of retinal damage in AMD. Additionally, activated complement mediators and some complement regulators, such as vitronectin, have been found not only in the drusen and adjacent retinal areas but also in the peripheral blood of patients with AMD. Therefore, we aim to provide a review of recently studied complement factors to highlight their role in the pathogenesis of AMD and to evaluate new potential therapeutic strategies.

Complement mediators in development to treat age-related macular degeneration / Nebbioso, M.; Franzone, F.; Lambiase, A.; Taurone, S.; Artico, M.; Gharbiya, M.; Greco, A.; Polimeni, A.. - In: DRUGS & AGING. - ISSN 1170-229X. - 39:2(2022), pp. 107-118. [10.1007/s40266-021-00914-x]

Complement mediators in development to treat age-related macular degeneration

Nebbioso M.
Co-primo
;
Franzone F.
Co-primo
;
Lambiase A.;Taurone S.;Artico M.;Gharbiya M.;Greco A.
Penultimo
;
Polimeni A.
Ultimo
2022

Abstract

Over recent years, great attention has been paid to the role of the complement system in the pathogenesis of age-related macular degeneration (AMD). In particular, several studies have highlighted a link between AMD development and complement dysregulation, which can probably be explained as a complement cascade hyperactivation resulting from the presence of a series of risk factors such as aging; smoking; obesity; alcohol consumption; exposure to pesticides, industrial chemicals, or pollution; and other causes of oxidative stress. This hypothesis has been mainly supported by the presence of complement mediators as constituents of drusen, representing one of the earliest and most characteristic signs of retinal damage in AMD. Additionally, activated complement mediators and some complement regulators, such as vitronectin, have been found not only in the drusen and adjacent retinal areas but also in the peripheral blood of patients with AMD. Therefore, we aim to provide a review of recently studied complement factors to highlight their role in the pathogenesis of AMD and to evaluate new potential therapeutic strategies.
File allegati a questo prodotto
File Dimensione Formato  
Nebbioso_Complement mediators_2022.pdf

solo gestori archivio

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 2.62 MB
Formato Adobe PDF
2.62 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Drugs&Aging 2022.pdf

solo gestori archivio

Tipologia: Licenza (contratto editoriale)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 2.53 MB
Formato Adobe PDF
2.53 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Drugs&Aging 2022.pdf

solo gestori archivio

Tipologia: Licenza (contratto editoriale)
Licenza: Tutti i diritti riservati (All rights reserved)
Dimensione 2.53 MB
Formato Adobe PDF
2.53 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1623196
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 3
  • ???jsp.display-item.citation.isi??? 3
social impact