Rectal neuroendocrine tumors (r‐NETs) are rare tumors with overall good prognosis after complete resection. However, there is no consensus on the extension of lymphadenectomy or regarding contraindications to extensive resection. In this study, we aim to identify predictive factors that correlate with nodal metastasis in patients affected by G1–G2 r‐NETs. A retrospective analysis of G1–G2 r‐NETs patients from eight tertiary Italian centers was performed. From January 1990 to January 2020, 210 patients were considered and 199 were included in the analysis. The data for nodal status were available for 159 cases. The nodal involvement rate was 9%. A receiver operating characteristic (ROC) curve analysis was performed to identify the diameter (>11.5 mm) and Ki‐67 (3.5%), respectively, as cutoff values to predict nodal involvement. In a multivariate analysis, diameter > 11.5 mm and vascular infiltration were independently correlated with nodal involvement. A risk scoring system was constructed using these two predictive factors. Tumor size and vascular invasion are predictors of nodal involvement. In addition, tumor size > 11.5 mm is used as a driving parameter of better‐tailored treatment during pre‐operative assessment. Data from prospective studies are needed to validate these results and to guide decision‐making in r‐ NETs patients in clinical practice.

Assessment of the Risk of Nodal Involvement in Rectal Neuroendocrine Neoplasms. The NOVARA Score, a Multicentre Retrospective Study / Ricci, A. D.; Pusceddu, S.; Panzuto, F.; Gelsomino, F.; Massironi, S.; De Angelis, C. G.; Modica, R.; Ricco, G.; Torchio, M.; Rinzivillo, M.; Prinzi, N.; Rizzi, F.; Lamberti, G.; Campana, D.. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 11:3(2022), pp. 1-10. [10.3390/jcm11030713]

Assessment of the Risk of Nodal Involvement in Rectal Neuroendocrine Neoplasms. The NOVARA Score, a Multicentre Retrospective Study

Panzuto F.;Rinzivillo M.;
2022

Abstract

Rectal neuroendocrine tumors (r‐NETs) are rare tumors with overall good prognosis after complete resection. However, there is no consensus on the extension of lymphadenectomy or regarding contraindications to extensive resection. In this study, we aim to identify predictive factors that correlate with nodal metastasis in patients affected by G1–G2 r‐NETs. A retrospective analysis of G1–G2 r‐NETs patients from eight tertiary Italian centers was performed. From January 1990 to January 2020, 210 patients were considered and 199 were included in the analysis. The data for nodal status were available for 159 cases. The nodal involvement rate was 9%. A receiver operating characteristic (ROC) curve analysis was performed to identify the diameter (>11.5 mm) and Ki‐67 (3.5%), respectively, as cutoff values to predict nodal involvement. In a multivariate analysis, diameter > 11.5 mm and vascular infiltration were independently correlated with nodal involvement. A risk scoring system was constructed using these two predictive factors. Tumor size and vascular invasion are predictors of nodal involvement. In addition, tumor size > 11.5 mm is used as a driving parameter of better‐tailored treatment during pre‐operative assessment. Data from prospective studies are needed to validate these results and to guide decision‐making in r‐ NETs patients in clinical practice.
endoscopic mucosal resection; endoscopic submucosal dissection; low anterior resection; lymph node metastasis; rectal neuroendocrine tumor
01 Pubblicazione su rivista::01a Articolo in rivista
Assessment of the Risk of Nodal Involvement in Rectal Neuroendocrine Neoplasms. The NOVARA Score, a Multicentre Retrospective Study / Ricci, A. D.; Pusceddu, S.; Panzuto, F.; Gelsomino, F.; Massironi, S.; De Angelis, C. G.; Modica, R.; Ricco, G.; Torchio, M.; Rinzivillo, M.; Prinzi, N.; Rizzi, F.; Lamberti, G.; Campana, D.. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 11:3(2022), pp. 1-10. [10.3390/jcm11030713]
File allegati a questo prodotto
File Dimensione Formato  
Ricci_AssessmentRisk-Neuroendocrine-Neoplasms_2022.pdf

accesso aperto

Tipologia: Versione editoriale (versione pubblicata con il layout dell'editore)
Licenza: Creative commons
Dimensione 779.99 kB
Formato Adobe PDF
779.99 kB Adobe PDF Visualizza/Apri PDF

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1623144
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 2
  • ???jsp.display-item.citation.isi??? 2
social impact