Objective: The aim of this study was to investigate everolimus efficacy in well-moderately differentiated pancreatic NEC (pNEC) G3. Methods: This was a retrospective analysis of patients with pNEC G3 and Ki67 20% to 55% treated with everolimus. Results: Fifteen patients with median Ki67 30%and Eastern Cooperative Oncology Group performance status 0 to 1 were evaluated. Of these, 4 patients received everolimus as first-line treatment, whereas 11 had been pretreated with chemotherapy or peptide receptor radionuclide therapy. Median progression-free survival was 6 months, and median overall survival was 28 months. Eleven patients achieved disease stabilization (DS) at 3 month follow-up. Six patients (40%) maintained DS for at least 12 months. Three of 4 patients who received everolimus as first-line therapy had sustained DS (progression-free survival, 12, 17, and 22 months). The safety profile was consistent with that previously reported, with adverse events occurring in 9 patients (66.7%). Conclusions: This study suggests that everolimus is active in pNECG3with well-moderately differentiated morphology andKi67 less than 55%, inwhich more toxic systemic chemotherapy is, to date, the only available treatment.

Everolimus in pancreatic neuroendocrine carcinomas G3 / Panzuto, F.; Rinzivillo, M.; Spada, F.; Antonuzzo, L.; Ibrahim, T.; Campana, D.; Fazio, N.; Delle Fave, G.. - In: PANCREAS. - ISSN 0885-3177. - 46:3(2017), pp. 302-305. [10.1097/MPA.0000000000000762]

Everolimus in pancreatic neuroendocrine carcinomas G3

Panzuto F.;Rinzivillo M.;Delle Fave G.
2017

Abstract

Objective: The aim of this study was to investigate everolimus efficacy in well-moderately differentiated pancreatic NEC (pNEC) G3. Methods: This was a retrospective analysis of patients with pNEC G3 and Ki67 20% to 55% treated with everolimus. Results: Fifteen patients with median Ki67 30%and Eastern Cooperative Oncology Group performance status 0 to 1 were evaluated. Of these, 4 patients received everolimus as first-line treatment, whereas 11 had been pretreated with chemotherapy or peptide receptor radionuclide therapy. Median progression-free survival was 6 months, and median overall survival was 28 months. Eleven patients achieved disease stabilization (DS) at 3 month follow-up. Six patients (40%) maintained DS for at least 12 months. Three of 4 patients who received everolimus as first-line therapy had sustained DS (progression-free survival, 12, 17, and 22 months). The safety profile was consistent with that previously reported, with adverse events occurring in 9 patients (66.7%). Conclusions: This study suggests that everolimus is active in pNECG3with well-moderately differentiated morphology andKi67 less than 55%, inwhich more toxic systemic chemotherapy is, to date, the only available treatment.
everolimus; grading; neuroendocrine carcinomas; pancreas
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Everolimus in pancreatic neuroendocrine carcinomas G3 / Panzuto, F.; Rinzivillo, M.; Spada, F.; Antonuzzo, L.; Ibrahim, T.; Campana, D.; Fazio, N.; Delle Fave, G.. - In: PANCREAS. - ISSN 0885-3177. - 46:3(2017), pp. 302-305. [10.1097/MPA.0000000000000762]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1623112
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