The study aimed to find biomarkers to characterize and differentiate healthy and pathological placentas using the nuclear magnetic resonance diffusion weighted imaging (DWI) technique. Fetal and maternal placentas tissues are characterized by a different diffusion behavior. Diffusion and perfusion can be quantified using intravoxel-incoherent-motion (IVIM) model of DWI signal acquired using a specific acquisition sequence. The dataset is divided into two groups: 33 healthy subjects and 15 pathological subjects classified as Fetal Growth Restriction (FGR) by an ultrasound investigation. The perfusion fraction f has a significant difference between fetal and maternal side which is connected to the role of the villi involved in the exchange of nutrients between fetal and maternal blood. It also discriminates healthy and FGR placentas. In conclusion, diffusion and perfusion of water quantified by DWI is a powerful non-invasive, radiation-free tool for prenatal diagnosis.
Molecular diffusion and perfusion of biological water quantified by MRI for the diagnosis of pathological human placentas / Maiuro, A.; Antonelli, A.; Manganaro, L.; Capuani, S.. - In: IL NUOVO CIMENTO C. - ISSN 2037-4909. - 43:4-5(2020). [10.1393/ncc/i2020-20124-2]
Molecular diffusion and perfusion of biological water quantified by MRI for the diagnosis of pathological human placentas
Maiuro A.Primo
;Antonelli A.Secondo
;Manganaro L.Penultimo
;Capuani S.Ultimo
2020
Abstract
The study aimed to find biomarkers to characterize and differentiate healthy and pathological placentas using the nuclear magnetic resonance diffusion weighted imaging (DWI) technique. Fetal and maternal placentas tissues are characterized by a different diffusion behavior. Diffusion and perfusion can be quantified using intravoxel-incoherent-motion (IVIM) model of DWI signal acquired using a specific acquisition sequence. The dataset is divided into two groups: 33 healthy subjects and 15 pathological subjects classified as Fetal Growth Restriction (FGR) by an ultrasound investigation. The perfusion fraction f has a significant difference between fetal and maternal side which is connected to the role of the villi involved in the exchange of nutrients between fetal and maternal blood. It also discriminates healthy and FGR placentas. In conclusion, diffusion and perfusion of water quantified by DWI is a powerful non-invasive, radiation-free tool for prenatal diagnosis.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
