Introduction: Despite substantial progress in the field, malaria remains a global health issue and currently available control strategies are not sufficient to achieve eradication. Agents able to prevent transmission are likely to have a strong impact on malaria control and have been prioritized as a primary objective to reduce the number of secondary infections. Therefore, there is an increased interest in finding novel drugs targeting sexual stages of Plasmodium and innovative methods to target malaria transmission from host to vector, and vice versa. Areas covered: This review covers innovative transmission-blocking inventions patented between 2015 and October 2021. The focus is on chemical interventions, which could be used as 'chemical vaccines' to prevent transmission (small molecules, carbohydrates, and polypeptides). Expert opinion: Even though the development of novel strategies to block transmission still requires fundamental additional research and a deeper understanding of parasite sexual stages biology, the research in this field has significantly accelerated. Among innovative inventions patented over the last 6 years, the surface-delivery of antimalarial drugs to kill transmission-stages parasites in mosquitoes holds the highest promise for success in malaria control strategies, opening completely new scenarios in malaria transmission-blocking drug discovery.

Malaria transmission blocking compounds: a patent review / Consalvi, Sara; Tammaro, Chiara; Appetecchia, Federico; Biava, Mariangela; Poce, Giovanna. - In: EXPERT OPINION ON THERAPEUTIC PATENTS. - ISSN 1354-3776. - 32:6(2022), pp. 1-18. [10.1080/13543776.2022.2049239]

Malaria transmission blocking compounds: a patent review

Sara Consalvi
Primo
;
Chiara Tammaro;Federico Appetecchia;Mariangela Biava;Giovanna Poce
2022

Abstract

Introduction: Despite substantial progress in the field, malaria remains a global health issue and currently available control strategies are not sufficient to achieve eradication. Agents able to prevent transmission are likely to have a strong impact on malaria control and have been prioritized as a primary objective to reduce the number of secondary infections. Therefore, there is an increased interest in finding novel drugs targeting sexual stages of Plasmodium and innovative methods to target malaria transmission from host to vector, and vice versa. Areas covered: This review covers innovative transmission-blocking inventions patented between 2015 and October 2021. The focus is on chemical interventions, which could be used as 'chemical vaccines' to prevent transmission (small molecules, carbohydrates, and polypeptides). Expert opinion: Even though the development of novel strategies to block transmission still requires fundamental additional research and a deeper understanding of parasite sexual stages biology, the research in this field has significantly accelerated. Among innovative inventions patented over the last 6 years, the surface-delivery of antimalarial drugs to kill transmission-stages parasites in mosquitoes holds the highest promise for success in malaria control strategies, opening completely new scenarios in malaria transmission-blocking drug discovery.
2022
antimalarials; drug discovery; gametocytes; malaria; plasmodium falciparum; sexual stages; transmission-blocking
01 Pubblicazione su rivista::01a Articolo in rivista
Malaria transmission blocking compounds: a patent review / Consalvi, Sara; Tammaro, Chiara; Appetecchia, Federico; Biava, Mariangela; Poce, Giovanna. - In: EXPERT OPINION ON THERAPEUTIC PATENTS. - ISSN 1354-3776. - 32:6(2022), pp. 1-18. [10.1080/13543776.2022.2049239]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1620087
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