RNA metabolism is central to cellular physiopathology. Almost all the molecular pathways underpinning biological processes are affected by the events governing the RNA life cycle, ranging from transcription to degradation. The deregulation of these processes contributes to the onset and progression of human diseases. In recent decades, considerable efforts have been devoted to the characterization of noncoding RNAs (ncRNAs) and to the study of their role in the homeostasis of the nervous system (NS), where they are highly enriched. Acting as major regulators of gene expression, ncRNAs orchestrate all the steps of the differentiation programs, participate in the mechanisms underlying neural functions, and are crucially implicated in the development of neuronal pathologies, among which are neurodegenerative diseases. This review aims to explore the link between ncRNA dysregulation and amyotrophic lateral sclerosis (ALS), the most frequent motoneuron (MN) disorder in adults. Notably, defective RNA metabolism is known to be largely associated with this pathology, which is often regarded as an RNA disease. We also discuss the potential role that these transcripts may play as diagnostic biomarkers and therapeutic targets.

RNA deregulation in Amyotrophic Lateral Sclerosis: The noncoding perspective / Laneve, P.; Tollis, P.; Caffarelli, E.. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1661-6596. - 22:19(2021). [10.3390/ijms221910285]

RNA deregulation in Amyotrophic Lateral Sclerosis: The noncoding perspective

Laneve P.
Primo
;
Tollis P.
Secondo
;
Caffarelli E.
Ultimo
2021

Abstract

RNA metabolism is central to cellular physiopathology. Almost all the molecular pathways underpinning biological processes are affected by the events governing the RNA life cycle, ranging from transcription to degradation. The deregulation of these processes contributes to the onset and progression of human diseases. In recent decades, considerable efforts have been devoted to the characterization of noncoding RNAs (ncRNAs) and to the study of their role in the homeostasis of the nervous system (NS), where they are highly enriched. Acting as major regulators of gene expression, ncRNAs orchestrate all the steps of the differentiation programs, participate in the mechanisms underlying neural functions, and are crucially implicated in the development of neuronal pathologies, among which are neurodegenerative diseases. This review aims to explore the link between ncRNA dysregulation and amyotrophic lateral sclerosis (ALS), the most frequent motoneuron (MN) disorder in adults. Notably, defective RNA metabolism is known to be largely associated with this pathology, which is often regarded as an RNA disease. We also discuss the potential role that these transcripts may play as diagnostic biomarkers and therapeutic targets.
2021
ALS; Circular RNAs; long noncoding RNAs; MicroRNAs; Motoneurons; neurodegeneration; Noncoding RNAs; RNA metabolism; Amyotrophic Lateral Sclerosis; animals; humans; motor neurons; neurodegenerative diseases; RNA, untranslated
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
RNA deregulation in Amyotrophic Lateral Sclerosis: The noncoding perspective / Laneve, P.; Tollis, P.; Caffarelli, E.. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1661-6596. - 22:19(2021). [10.3390/ijms221910285]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1619757
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