Anaphylaxis is defined as a rapid systemic reaction that develops in individuals previously exposed to specific allergens. The new exposure causes systemic cellular degranulation, which in turn leads to cardiovascular and respiratory changes that are fatal if not treated immediately. One of the main problems of this scenario in the forensic field is the determination of a correct post-mortem diagnosis. Traditional methods, such as histopathological examination of the respiratory tract and the use of specific antibodies used in immunohistochemistry, are sensitive but not always specific and therefore do not guarantee a high degree of probability in the diagnosis of anaphylaxis. For this reason, a new and promising research frontier in this field of forensic pathology could be represented by the application of miRNAs as biomarkers, as has been done in other areas of medicine..

Comparative study between conventional and new methods in defining the cause of death from anaphylactic shock / Costantino, A.; Mezzetti, E.; de Matteis, A.; Volonnino, G.; de Simone, S.; Fazio, V.. - In: LA CLINICA TERAPEUTICA. - ISSN 0009-9074. - 172:4(2021), pp. 369-371. [10.7417/CT.2021.2342]

Comparative study between conventional and new methods in defining the cause of death from anaphylactic shock

Mezzetti E.;de Matteis A.;Volonnino G.;Fazio V.
2021

Abstract

Anaphylaxis is defined as a rapid systemic reaction that develops in individuals previously exposed to specific allergens. The new exposure causes systemic cellular degranulation, which in turn leads to cardiovascular and respiratory changes that are fatal if not treated immediately. One of the main problems of this scenario in the forensic field is the determination of a correct post-mortem diagnosis. Traditional methods, such as histopathological examination of the respiratory tract and the use of specific antibodies used in immunohistochemistry, are sensitive but not always specific and therefore do not guarantee a high degree of probability in the diagnosis of anaphylaxis. For this reason, a new and promising research frontier in this field of forensic pathology could be represented by the application of miRNAs as biomarkers, as has been done in other areas of medicine..
2021
anaphylactic shock; anaphylaxis; anti-cd117; forensic medicine; immunohistochemistry; lte4; mast cell; mirna; tryptase; anaphylaxis; autopsy; biomarkers; forensic pathology; humans; tryptases; cause of death
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Comparative study between conventional and new methods in defining the cause of death from anaphylactic shock / Costantino, A.; Mezzetti, E.; de Matteis, A.; Volonnino, G.; de Simone, S.; Fazio, V.. - In: LA CLINICA TERAPEUTICA. - ISSN 0009-9074. - 172:4(2021), pp. 369-371. [10.7417/CT.2021.2342]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1619509
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