Neuroglobin is expressed in vertebrate brain and belongs to a branch of the globin family that diverged early in evolution. Sequence conservation and presence in nervous cells of several taxa suggests a relevant role in the nervous system, with tight structural restraints. Twenty years after its discovery, a rich scientific literature provides convincing evidence of the involvement of neuroglobin in sustaining neuron viability in physiological and pathological conditions however, a full and conclusive picture of its specific function, or set of functions is still lacking. The difficulty of unambiguously assigning a precise mechanism and biochemical role to neuroglobin might arise from the participation to one or more cell mechanism that redundantly guarantee the functioning of the highly specialized and metabolically demanding central nervous system of vertebrates. Here we collect findings and hypotheses arising from recent biochemical, biophysical, structural, in cell and in vivo experimental work on neuroglobin, aiming at providing an overview of the most recent literature. Proteins are said to have jobs and hobbies, it is possible that, in the case of neuroglobin, evolution has selected for it more than one job, and support to cover for its occasional failings. Disentangling the mechanisms and roles of neuroglobin is thus a challenging task that might be achieved by considering data from different disciplines and experimental approaches.

Neuroglobin, clues to function and mechanism / Exertier, C.; Montemiglio, L. C.; Freda, I.; Gugole, E.; Parisi, G.; Savino, C.; Vallone, B.. - In: MOLECULAR ASPECTS OF MEDICINE. - ISSN 0098-2997. - 84:(2022), p. 101055. [10.1016/j.mam.2021.101055]

Neuroglobin, clues to function and mechanism

Exertier C.;Montemiglio L. C.;Freda I.;Gugole E.;Savino C.;Vallone B.
2022

Abstract

Neuroglobin is expressed in vertebrate brain and belongs to a branch of the globin family that diverged early in evolution. Sequence conservation and presence in nervous cells of several taxa suggests a relevant role in the nervous system, with tight structural restraints. Twenty years after its discovery, a rich scientific literature provides convincing evidence of the involvement of neuroglobin in sustaining neuron viability in physiological and pathological conditions however, a full and conclusive picture of its specific function, or set of functions is still lacking. The difficulty of unambiguously assigning a precise mechanism and biochemical role to neuroglobin might arise from the participation to one or more cell mechanism that redundantly guarantee the functioning of the highly specialized and metabolically demanding central nervous system of vertebrates. Here we collect findings and hypotheses arising from recent biochemical, biophysical, structural, in cell and in vivo experimental work on neuroglobin, aiming at providing an overview of the most recent literature. Proteins are said to have jobs and hobbies, it is possible that, in the case of neuroglobin, evolution has selected for it more than one job, and support to cover for its occasional failings. Disentangling the mechanisms and roles of neuroglobin is thus a challenging task that might be achieved by considering data from different disciplines and experimental approaches.
2022
Heme proteins; neuroglobin; neuroprotection; oxidative stress; signaling pathways; structure-function relationship
01 Pubblicazione su rivista::01g Articolo di rassegna (Review)
Neuroglobin, clues to function and mechanism / Exertier, C.; Montemiglio, L. C.; Freda, I.; Gugole, E.; Parisi, G.; Savino, C.; Vallone, B.. - In: MOLECULAR ASPECTS OF MEDICINE. - ISSN 0098-2997. - 84:(2022), p. 101055. [10.1016/j.mam.2021.101055]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1617165
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