Abstract Background: The nucleolus is a subnuclear, non-membrane bound domain that is the hub of ribosome biogenesis and a critical regulator of cell homeostasis. Rapid growth and division of cells in tumors are correlated with intensive nucleolar metabolism as a response to oncogenic factors overexpression. Several members of the Epidermal Growth Factor Receptor (EGFR) family, have been identifed in the nucleus and nucleolus of many cancer cells, but their function in these compartments remains unexplored. Results: We focused our research on the nucleolar function that a specifc member of EGFR family, the ErbB3 receptor, plays in glioblastoma, a tumor without efective therapies. Here, Neuregulin 1 mediated proliferative stimuli, promotes ErbB3 relocalization from the nucleolus to the cytoplasm and increases pre-rRNA synthesis. Instead ErbB3 silencing or nucleolar stress reduce cell proliferation and afect cell cycle progression. Conclusions: These data point to the existence of an ErbB3-mediated non canonical pathway that glioblastoma cells use to control ribosomes synthesis and cell proliferation. These results highlight the potential role for the nucleolar ErbB3 receptor, as a new target in glioblastoma.

Nucleolar localization of the ErbB3 receptor as a new target in glioblastoma / Tagliaferro, Marzia; Rosa, Paolo; Carlo Bellenchi, Gian; Bastianelli, Daniela; Trotta, Rosa; Tito, Claudia; Fazi, Francesco; Calogero, Antonella; Ponti, Donatella. - In: BMC MOLECULAR AND CELL BIOLOGY. - ISSN 2661-8850. - 23:1(2022), pp. 1-14. [10.1186/s12860-022-00411-y]

Nucleolar localization of the ErbB3 receptor as a new target in glioblastoma

Paolo Rosa
Co-primo
;
Daniela Bastianelli;Claudia Tito;Francesco Fazi;Antonella Calogero
Penultimo
;
Donatella Ponti
Ultimo
2022

Abstract

Abstract Background: The nucleolus is a subnuclear, non-membrane bound domain that is the hub of ribosome biogenesis and a critical regulator of cell homeostasis. Rapid growth and division of cells in tumors are correlated with intensive nucleolar metabolism as a response to oncogenic factors overexpression. Several members of the Epidermal Growth Factor Receptor (EGFR) family, have been identifed in the nucleus and nucleolus of many cancer cells, but their function in these compartments remains unexplored. Results: We focused our research on the nucleolar function that a specifc member of EGFR family, the ErbB3 receptor, plays in glioblastoma, a tumor without efective therapies. Here, Neuregulin 1 mediated proliferative stimuli, promotes ErbB3 relocalization from the nucleolus to the cytoplasm and increases pre-rRNA synthesis. Instead ErbB3 silencing or nucleolar stress reduce cell proliferation and afect cell cycle progression. Conclusions: These data point to the existence of an ErbB3-mediated non canonical pathway that glioblastoma cells use to control ribosomes synthesis and cell proliferation. These results highlight the potential role for the nucleolar ErbB3 receptor, as a new target in glioblastoma.
2022
ErbB3; neuregulin; nucleolus; UBF; nucleolin; glioblastoma; actinomycin D
01 Pubblicazione su rivista::01a Articolo in rivista
Nucleolar localization of the ErbB3 receptor as a new target in glioblastoma / Tagliaferro, Marzia; Rosa, Paolo; Carlo Bellenchi, Gian; Bastianelli, Daniela; Trotta, Rosa; Tito, Claudia; Fazi, Francesco; Calogero, Antonella; Ponti, Donatella. - In: BMC MOLECULAR AND CELL BIOLOGY. - ISSN 2661-8850. - 23:1(2022), pp. 1-14. [10.1186/s12860-022-00411-y]
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11573/1616393
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