Weather and the susceptibility of children to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is still a debated question and currently a hot topic, particularly in view of important decisions regarding opening schools. Therefore, we performed this prospective analysis of anti-SARS-CoV-2 immunoglobulin G (IgG) antibodies in children with known household exposure to SARS-CoV-2 and compared their IgG status with the other adults exposed to the index case in the same household. A total of 30 families with a documented COVID-19 index case were included. A total of 44 out of 80 household contacts (55%) of index patients had anti SARS-CoV-2 IgG antibodies. In particular, 16/27 (59,3%) adult partners had IgG antibodies compared with 28/53 (52,3%) of pediatric contacts (p >.05). Among the pediatric population, children ≥5 years of age had a similar probability of having SARS-CoV-2 IgG antibodies (21/39, 53.8%) compared to those less than 5 years old (7/14, 50%) (p >.05). Adult partners and children also had a similar probability of having SARS-CoV-2 IgG antibodies. Interestingly, 10/28 (35.7%) of children and 5/27 (18.5%) of adults with SARS-CoV-2 IgG antibodies were previously diagnosed as COVID-19 cases. Our study shows evidence of a high rate of IgG antibodies in children exposed to SARS-CoV-2. This report has public health implications, highlighting the need to establish appropriate guidelines for school openings and other social activities related to childhood.
Seroprevalence of anti-SARS-CoV-2 IgG antibodies in children with household exposure to adults with COVID-19: Preliminary findings / Buonsenso, D.; Valentini, P.; De Rose, C.; Pata, D.; Sinatti, D.; Speziale, D.; Ricci, R.; Carfi, A.; Landi, F.; Ferrari, V.; De Maio, F.; Palucci, I.; Sanguinetti, M.; Sali, M.; Landi, F.; Gremese, E.; Bernabei, R.; Fantoni, M.; Gasbarrini, A.; Settanni, C. R.; Benvenuto, F.; Bramato, G.; Carfi, A.; Ciciarello, F.; Lo Monaco, M. R.; Martone, A. M.; Marzetti, E.; Napolitano, C.; Pagano, F.; Rocchi, S.; Rota, E.; Salerno, A.; Tosato, M.; Tritto, M.; Calvani, R.; Catalano, L.; Picca, A.; Savera, G.; Cauda, R.; Tamburrini, E.; Borghetti, A.; Di Gianbenedetto, S.; Murri, R.; Cingolani, A.; Ventura, G.; Taddei, E.; Moschese, D.; Ciccullo, A.; Stella, L.; Addolorato, G.; Franceschi, F.; Mingrone, G.; Zocco, M. A.; Cattani, P.; Marchetti, S.; Posteraro, B.; Sali, M.; Bizzarro, A.; Lauria, A.; Rizzo, S.; Savastano, M. C.; Gambini, G.; Cozzupoli, G. M.; Culiersi, C.; Passali, G. C.; Paludetti, G.; Galli, J.; Crudo, F.; Di Cintio, G.; Longobardi, Y.; Tricarico, L.; Santantonio, M.; Buonsenso, D.; Valentini, P.; Pata, D.; Sinatti, D.; De Rose, C.; Richeldi, L.; Lombardi, F.; Calabrese, A.; Sani, G.; Janiri, D.; Giuseppin, G.; Molinaro, M.; Modica, M.; Natale, L.; Larici, A. R.; Marano, R.; Paglionico, A.; Petricca, L.; Gigante, L.; Natalello, G.; Fedele, A. L.; Lizzio, M. M.; Tolusso, B.; Alivernini, S.; Santoliquido, A.; Santoro, L.; Nesci, A.; Popolla, V.. - In: PEDIATRIC PULMONOLOGY. - ISSN 8755-6863. - 56:6(2021), pp. 1374-1377. [10.1002/ppul.25280]
Seroprevalence of anti-SARS-CoV-2 IgG antibodies in children with household exposure to adults with COVID-19: Preliminary findings
De Rose C.;Ciciarello F.;Picca A.;Murri R.;Taddei E.;Franceschi F.;Bizzarro A.;Lauria A.;Di Cintio G.;De Rose C.;Sani G.;Janiri D.;Gigante L.;
2021
Abstract
Weather and the susceptibility of children to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is still a debated question and currently a hot topic, particularly in view of important decisions regarding opening schools. Therefore, we performed this prospective analysis of anti-SARS-CoV-2 immunoglobulin G (IgG) antibodies in children with known household exposure to SARS-CoV-2 and compared their IgG status with the other adults exposed to the index case in the same household. A total of 30 families with a documented COVID-19 index case were included. A total of 44 out of 80 household contacts (55%) of index patients had anti SARS-CoV-2 IgG antibodies. In particular, 16/27 (59,3%) adult partners had IgG antibodies compared with 28/53 (52,3%) of pediatric contacts (p >.05). Among the pediatric population, children ≥5 years of age had a similar probability of having SARS-CoV-2 IgG antibodies (21/39, 53.8%) compared to those less than 5 years old (7/14, 50%) (p >.05). Adult partners and children also had a similar probability of having SARS-CoV-2 IgG antibodies. Interestingly, 10/28 (35.7%) of children and 5/27 (18.5%) of adults with SARS-CoV-2 IgG antibodies were previously diagnosed as COVID-19 cases. Our study shows evidence of a high rate of IgG antibodies in children exposed to SARS-CoV-2. This report has public health implications, highlighting the need to establish appropriate guidelines for school openings and other social activities related to childhood.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
